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RADIAL FLOW BIOREACTOR FOR ANCHORAGE-DEPENDENT CELLS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7294
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7294
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Sepragen Corpon
Po Box 5155 Hercules, CA 94547
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: RADIAL FLOW BIOREACTOR FOR ANCHORAGE-DEPENDENT CELLS
Agency: HHS
Contract: N/A
Award Amount: $49,000.00
 

Abstract:

THE PURPOSE OF THE RESEARCH IS TO DEVELOP A CELL-CULTURE GROWTH CHAMBER FOR ANCHORAGE-DEPENDENT CELLS THAT IS CAPABLEOF ACHIEVING HIGH CELL DENSITIES AND CAN BE EASILY SCALED UP. SUCH A CHAMBER CAN BE USED FOR THE ECONOMICAL PRODUCTION OF A NUMBER OF IMPORTANT THERAPEUTIC AND DIAGNOSTIC SUBSTANCES THAT CANNOT BE PRODUCED FROM ANIMAL TISSUE OR BACTERIAL SYSTEMS. THE CULTURE CHAMBER WILL BE DESIGNED SO THAT THERE IS A TRANSVERSE FLOW OF CULTURE MEDIUM ACROSS A PACKED BED OF MICROCARRIERS WITH ATTACHED CELLS. A UNIQUE DESIGN, BASED ON RADIAL FLOW DYNAMICS, SHOULD MINIMIZE THE NONOPTIMAL CULTURE-PERFUSION PROBLEMS THAT ARE CHARACTERISTIC OF OTHER LARGE-SCALE CULTURE METHODSAND SHOULD MAXIMIZE THE UNIFORMITY OF MEDIUM DELIVERY AND CELL VIABILITY. BECAUSE ANCHORAGE-DEPENDENT CELLS ARE BECOMING INCREASINGLY IMPORTANT FOR THE PRODUCTION OF VALUABLE BIOMOLECULES, AND BECAUSE THE COMPETITIVE CELL-GROWTH TECHNOLOGIES THAT EXIST SUFFER FROM A NUMBER OF PITFALLS, THERE APPEARS TO BE CONSIDERABLE APPLICATION FOR THIS RESEARCH.

Principal Investigator:

Barry d schwartz phd
4157245400

Business Contact:

Small Business Information at Submission:

Sepragen Corpon
Po Box 5155 Hercules, CA 94547

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No