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Control of Biofilms by Natural Products

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
53969
Program Year/Program:
2001 / STTR
Agency Tracking Number:
1R41RR016363-01
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SEQUOIA SCIENCES, INC.
SEQUOIA SCIENCES, INC. 1912 INNERBELT BUSINESS CENTER DR SAINT LOUIS, MO 63114-5760
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: Control of Biofilms by Natural Products
Agency: HHS
Contract: PHS2001-2
Award Amount: $194,500.00
 

Abstract:

DESCRIPTION (provided by applicant): The importance of Biofilms in chronic and treatment-resistant infectious disease, increasingly is clear. Biofilms also are a major problem in industrial processes. The focus of this proposal is to develop methods for discovering compounds that block and/or reverse biofilm formation, and to discover, and structurally characterize, active compounds. Specifically, we will develop efficient methods to screen extracts and compounds for their ability to regulate biofilms of a gram negative pathogen, and develop and validate new screens with biofilms of gram negative bacteria and fungi. In addition, we will evaluate plants, especially those that live in moist or wet environments, as a possible rich source of novel compounds that block or reverse biofilm formation. Compounds will be isolated and characterized with sensitive, high-throughput parallel LC-MS and LC-NMR. Once we define rich sources of compounds, effective assays, and identify new compounds that can block or reverse biofilm formation in Phase I, in Phase II we will use methods optimized here, and further characterize the biological activity of active compounds, to determine their potential for application(s) in protection against biofilm-related damage and disease, and the effectiveness of our methods for discovering valuable compounds. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

Principal Investigator:

John W. Costerton
4069944774
BILL_C@ERC.MONTANA.EDU

Business Contact:

Eldrdige, gary
8586230800
GELDRIDGE@SEQUOIASCIENCES.COM
Small Business Information at Submission:

SEQUOIA SCIENCES
11199 SORRENTO VALLEY RD, STE H SAN DIEGO, CA 92121-1334 SAN DIEGO, CA 92121

EIN/Tax ID: 330921231
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
MONTANA STATE UNIVERSITY
MONTANA STATE UNIVERSITY
BOZEMAN, MT 94785
RI Type: Nonprofit college or university