Not Available Ground Moving Target Indicator (GMTI) radar is designed to suppress returns from stationary background (clutter) in order to detect and track moving objects which would otherwise be obscured. However, many applications of GMTI, such as the military applications of tracking and… More

DESCRIPTION: (Applicant's Description) The overall goal of this project is to develop a commercially viable bacterial toxin-VEGF (vascular endothelial growth… More

DESCRIPTION: (Applicant's Description) The overall goal of this project is to develop a commercially viable bacterial toxin-VEGF (vascular endothelial growth… More

70733 Because the growth of primary tumor and metastatic lesions beyond a few millimeters requires formation of new blood vessels (angiogenesis), the targeted delivery of cytotoxic drugs to growing tumor blood vessels may form the basis for a highly selective anti-cancer therapy. Particularly… More

70733S02-II Because the growth of primary tumor and metastatic lesions beyond a few millimeters requires formation of new blood vessels (angiogenesis), the targeted delivery of cytotoxic drugs to growing tumor blood vessels may form the basis for a highly selective cancer therapy. Particularly… More

Anti-cancer antibodies are potential molecular vehicles for targeted delivery of therapeutic and diagnostic agents to tumors and metastatic lesions. Currently,

70733S02-II Because the growth of primary tumor and metastatic lesions beyond a few millimeters requires formation of new blood vessels (angiogenesis), the targeted delivery of cytotoxic drugs to growing tumor blood vessels may form the basis for a highly selective cancer therapy. Particularly… More

DESCRIPTION (provided by applicant): The overall goal of this project is the development of drug delivery vehicle that selectively targets cells affected by the anthrax toxin. The anticipated advantage of this system will be a decrease in side effects associated with systemic delivery of any… More

DESCRIPTION (provided by applicant): The overall goal of this project is to develop a pro-angiogenic wound-healing implant. New tissue that replaces a wound should be vascularized through a process known as angiogenesis. Vascular endothelial growth factor (VEGF) is the major pro-angiogenic factor… More

DESCRIPTION (provided by applicant): The overall goal of this project is to develop a highly sensitive system for cancer diagnostics based on targeted imaging of tumor neovasculature. Formation of new blood vessels through processes of angiogenesis and vasculogenesis is common, unique, and one of… More

DESCRIPTION (provided by applicant): Heart failure is the major cause of morbidity and mortality worldwide. It is recognized that cardiomyocyte apoptosis plays an important role in heart failure. Intracellular proteases, known as caspases, play crucial rol e in initiation and execution of apoptosis.… More

DESCRIPTION (provided by applicant): The overall goal of this project is to develop a system for targeted delivery of anthrax toxin inhibitors. Antibiotic treatment currently approved as a post-exposure anthrax therapy is not effective against toxemia, whi ch is induced by anthrax toxins comprising… More

The DOE is seeking radiolabeled compounds that have applications as radiotracers for radionuclide imaging technologies, such as positron emission tomography and single photon emission computed tomography. In response, this project will develop 64Cu-labeled epidermal growth factor (EGF) as a… More

DESCRIPTION (provided by applicant): There is an unmet need in a diagnostic procedure for colorectal cancer that relies on imaging of an early, specific, and well-understood molecular biomarker. We hypothesized that abnormally expressed receptors for vascu lar endothelial growth factor (VEGFR) are… More

DESCRIPTION (provided by applicant): The overall goal of this project is development of targeted PET probes for molecular imaging of receptors for vascular endothelial growth factor (VEGF), a crucial drug target in oncology patients. Tumor imaging with FDG , as well as imaging of tumor vasculature… More

DESCRIPTION (provided by applicant): The overall goal of this project is to develop targeted probes for imaging receptors for vascular endothelial growth factor (VEGF) in tumor angiogenesis. Overexpressed VEGF receptors play the crucial role in the onset a nd progression of tumor angiogenesis and… More

DESCRIPTION (provided by applicant): Drug-resistant breast cancer cells are the main cause of recurrent disease. One mechanism of cancer cell survival and drug resistance is mobilization of GRP78/BiP, master-regulator of unfolded protein response and ER st ress. Because of its role, GRP78/BiP is… More

The progression of rheumatoid arthritis (RA), specifically, the growth of the bone-destroying pannus in RA joints, depends on the formation of new blood vessels, whose growth is mediated primarily by vascular endothelial growth factor (VEGF) and its cognate receptors. VEGF and its receptors are… More

DESCRIPTION (provided by applicant): Our goal is to develop a targeted anti-cancer 177Lu radiotherapeutic agent that localizes to a tumor via receptor- mediated uptake by endothelial cells in the tumor vasculature. Due to beta emission (1.5 mm max dept h) 177Lu radiopharmaceutical is expected to… More

DESCRIPTION (provided by applicant): Myocardial infarction is a disabling disease, with infarct size being a major determinant of mortality. To limit infarct size and improve functional recovery, the ischemic myocardium has to be reperfused. However, reper fusion itself causes irreversible damage to… More

DESCRIPTION (provided by applicant): We propose to develop a contrast agent for photoacoustic imaging targeted to the receptors of vascular endothelial growth factor (VEGFR), so it can be accumulated and retained in tumor endothelial cells by VEGFR-mediated endocytosis. VEGFR are over expressed in… More

DESCRIPTION (provided by applicant): Currently available anti-angiogenic drugs inhibit VEGF/VEGFR signaling, which leads to transient vascular regression followed by rebound of drug-resistant vasculature, which significantly decrease the therapeutic efficacy of very expensive anti-angiogenic… More