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VEGF-Based Delivery of Boron Therapeutics
- Small Business Information
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Woman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
- Phase 1
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Fiscal Year: 2002Title: VEGF-Based Delivery of Boron TherapeuticsAgency: DOEContract: DE-FG02-02ER83520Award Amount: $99,510.00
Abstract:
70733 Because the growth of primary tumor and metastatic lesions beyond a few millimeters requires formation of new blood vessels (angiogenesis), the targeted delivery of cytotoxic drugs to growing tumor blood vessels may form the basis for a highly selective anti-cancer therapy. Particularly attractive are two-step therapies that initially deliver relatively non-toxic ¿prodrugs¿ that are subsequently activated at the sites of angiogenesis. This project will develop a two-step therapy that relies on the highly targeted delivery of non-toxic boron-10 (10B) containing polymers to growing endothelial cells at the sites of angiogenesis. Upon irradiation with low-energy neutrons, 10B atoms capture them, undergo nuclear fission, and yield high-energy products that destroy cells. Phase I will construct and test in vitro nanovehicles for boron-10 delivery that are targeted by the highly specific vascular endothelial growth factor. These nanovehicles will carry a high capacity cargo module containing a polymeric carrier for boron-10. The cargo module will be non-covalently docked to a specialized ¿docking tag¿ engineered into vascular endothelial growth factor. Commercial Applications and Other Benefits as described by the awardee: Targeted boron-10 therapeutics may provide an attractive alternative to highly toxic systemic chemo- and radiotherapy of cancer.Small Business Information at Submission:Sibtech, Inc.
705 North Mountain Road Newington, CT 06111EIN/Tax ID: 133992292DUNS: N/ANumber of Employees: N/AWoman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
Award Information
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Agency: Department of Energy |
Branch: N/A |
Award ID: 57105 |
Program Year/Program: 2002 / SBIR |
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Agency Tracking Number: 70733S02-I |
Solicitation Year: N/A |
Solicitation Topic Code: N/A |
Solicitation Number: N/A |