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VEGF-Based Delivery of Boron Therapeutics

Award Information

Agency:
Department of Energy
Branch:
N/A
Award ID:
57105
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
70733S02-I
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SIBTECH, INC.
115A Commerce Drive Brookfield, CT 06804-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: VEGF-Based Delivery of Boron Therapeutics
Agency: DOE
Contract: DE-FG02-02ER83520
Award Amount: $99,510.00
 

Abstract:

70733 Because the growth of primary tumor and metastatic lesions beyond a few millimeters requires formation of new blood vessels (angiogenesis), the targeted delivery of cytotoxic drugs to growing tumor blood vessels may form the basis for a highly selective anti-cancer therapy. Particularly attractive are two-step therapies that initially deliver relatively non-toxic ¿prodrugs¿ that are subsequently activated at the sites of angiogenesis. This project will develop a two-step therapy that relies on the highly targeted delivery of non-toxic boron-10 (10B) containing polymers to growing endothelial cells at the sites of angiogenesis. Upon irradiation with low-energy neutrons, 10B atoms capture them, undergo nuclear fission, and yield high-energy products that destroy cells. Phase I will construct and test in vitro nanovehicles for boron-10 delivery that are targeted by the highly specific vascular endothelial growth factor. These nanovehicles will carry a high capacity cargo module containing a polymeric carrier for boron-10. The cargo module will be non-covalently docked to a specialized ¿docking tag¿ engineered into vascular endothelial growth factor. Commercial Applications and Other Benefits as described by the awardee: Targeted boron-10 therapeutics may provide an attractive alternative to highly toxic systemic chemo- and radiotherapy of cancer.

Principal Investigator:

Joseph M. Backer
8609531164
jbacker@sibtech.com

Business Contact:

Joseph M. Backer
70733
8609531164
jbacker@sibtech.com
Small Business Information at Submission:

Sibtech, Inc.
705 North Mountain Road Newington, CT 06111

EIN/Tax ID: 133992292
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No