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A Topical Non Steroidal Anti-inflammatory for Rosacea

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
88678
Program Year/Program:
2009 / SBIR
Agency Tracking Number:
AI062034
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SIGNUM BIOSCIENCES
7 DEER PARK DR, STE H MONMOUTH JUNCTION, NJ -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2009
Title: A Topical Non Steroidal Anti-inflammatory for Rosacea
Agency: HHS
Contract: 2R44AI062034-02
Award Amount: $1,568,458.00
 

Abstract:

DESCRIPTION (provided by applicant): Isoprenylcysteine (IPC) analogs modulate heterotrimeric G-protein coupled receptor (GPCR) signaling pathways, representing a novel class of topical anti-inflammatory compounds whose action is restricted to the site of a pplication. Studies performed in the Phase I proposal demonstrate that IPC analogs have a wide spectrum of anti-inflammatory activities with a superior safety profile to glucocorticoids. Signum's proof of concept IPC analog, AFC, inhibited erythema (rednes s) in a double blind, vehicle controlled cosmetic human use study. More potent IPC analogs serve as attractive drug development candidates for reducing erythema and treating rosacea. Several IPC analogs identified from Signum's screening program are attrac tive candidates for preclinical development. The proposed Phase II research plan will identify one lead compound and two backups for preclinical development and will establish the analytical methods, process development and formulation that are necessary. Furthermore, these studies will determine the preclinical safety profile of the lead compound by performing metabolic, pharmacokinetic, toxicology and safety pharmacology studies. Together, the data generated from these studies will allow Signum to prepare and submit an IND for treatment of rosacea. PUBLIC HEALTH RELEVANCE: Rosacea is a common, chronic cutaneous condition afflicting millions of individuals. FDA approved treatments have yielded mixed results, often leaving patients with significant levels of facial redness. Successful pharmaceutical development of IPC analog anti-inflammatories will provide an important additional, and potentially better, therapeutic option for people suffering from rosacea redness.

Principal Investigator:

Joel S. Gordon
7323296344
JSGORDON@SIGNUMBIO.COM

Business Contact:

Eduardo Perex
eperez@signumbio.com
Small Business Information at Submission:

SIGNUM BIOSCIENCES
SIGNUM BIOSCIENCES 7 DEER PARK DR, STE H MONMOUTH JUNCTION, NJ -

EIN/Tax ID: 101061574
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No