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A Handheld Monitoring System For Biomarkers Of Response From Blood

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-05-C-0043
Agency Tracking Number: A043-179-3447
Amount: $728,140.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: A04-179
Solicitation Number: 2004.3
Timeline
Solicitation Year: 2004
Award Year: 2006
Award Start Date (Proposal Award Date): 2006-01-25
Award End Date (Contract End Date): 2008-05-24
Small Business Information
3130 Highland Avenue, 3rd Floor
Cincinnati, OH 45219
United States
DUNS: 142009583
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Jae Lee
 CEO, Managing Member
 (513) 475-6650
 jae.lee@siloambio.com
Business Contact
 Jae Lee
Title: CEO, Managing Member
Phone: (513) 475-6650
Email: jae.lee@siloambio.com
Research Institution
N/A
Abstract

The goal of this SBIR Phase II effort is the development of a prototype system for point-of-care monitoring of biomarkers of exposure. Two biochips will be developed for: (a) Cholinesterase panel - monitoring Acetylcholinesterase and Butyrylcholinesterase activities as biomarkers of exposure to organophosphates/ nerve-gas and (b) Heavy metal panel - monitoring Metallothionein and free blood lead level (using lead antibody) as biomarkers for metal exposure. The effort will also include development of a handheld analyzer using commercially available components. This work proposes two novel approaches for monitoring the activity of the cholinesterase enzymes. It is expected that the novel approaches will be at least 10 and as much as 1000 times more sensitive than the current techniques. During Phase I efforts we have successfully demonstrated proof-of-concepts for the key aspects of this work. The prototype biochip developed through this work will have an integrated sampling microneedle, require minimal sample volume (~ 1 microliter), and be capable of analyzing the targets in ~ 5 minutes. The research team includes members who are renowned experts in their area, with specific backgrounds in BioMEMS device development (at Siloam Biosciences) and identification/detection of biomarkers of exposure (at Center of Environmental Genetics, University of Cincinnati).

* Information listed above is at the time of submission. *

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