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Protein Microarray System for Rheumatoid Arthritis

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
85251
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
AI066482
Solicitation Year:
N/A
Solicitation Topic Code:
NIAID
Solicitation Number:
N/A
Small Business Information
CIENCIA, INC.
111 ROBERTS ST, STE K EAST HARTFORD, CT -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2010
Title: Protein Microarray System for Rheumatoid Arthritis
Agency: HHS
Contract: 2R44AI066482-02
Award Amount: $1,038,958.00
 

Abstract:

DESCRIPTION (provided by applicant): The long-term objective of the proposed effort is to develop an autonomous clinical diagnostics system for monitoring normal and diseased immune function that occurs in the context of rheumatoid arthritis, infection , inflammation, asthma, autoimmune disease, and neoplasia. This system will be a microarray-based bioassay platform that specifically captures distinct cell types and soluble macromolecules from a patient's blood sample onto spatially separate regions on a biosensor chip. Initial capture of macromolecules and cells can be quantified to assess the presence of specific subpopulations of leukocytes, cytokines, antibodies and other immunologically relevant molecules. Subsequent culture of the captured cells und er different conditions can be used to measure the production of specific cell products in real time to assess immune cell functional capacities. The technology allows for highly parallel measurements that result in the capability to perform hundreds of in dividual functional cellular assays simultaneously without the use of molecular labels. The system will enable assessment of patients' immune capacity in near-real time using microliter-scaled samples of blood readily harvested with minimally invasive proc edures (e.g., fingerstick capillary blood sampling). Such real-time measurements will be crucial for the ongoing monitoring of disease progression as well as the evaluation of prophylactic treatments and therapeutic manipulations that sustain and support i mmune mechanisms. PUBLIC HEALTH RELEVANCE: This project will develop tools that will enable improved diagnostics for rheumatoid arthritis, autoimmune diseases, and for infectious diseases.

Principal Investigator:

Ernest F. Guignon
8605289737
EFG@CIENCIA.COM

Business Contact:

Arturo O. Pilar
apilar@ciencia.com
Small Business Information at Submission:

CIENCIA, INC.
CIENCIA, INC. 111 ROBERTS ST, STE K EAST HARTFORD, CT -

EIN/Tax ID: 163100979
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No