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Microcarriers designed for protein & sera free media

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
71644
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
GM070195
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Solohill Engineering, Inc.
Solohill Engineering, Inc. 4220 Varsity Dr, Ste A Ann Arbor, MI 48108-0500
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2005
Title: Microcarriers designed for protein & sera free media
Agency: HHS
Contract: 2R44GM070195-02
Award Amount: $729,271.00
 

Abstract:

DESCRIPTION (provided by applicant): The overall goal of this SBIR Phase II application is to develop a family of microcarrier products that have a synthetic or recombinant collagen peptide bound to the bead surface. These microcarrier products would replace current microcarriers that have porcine collagen (i.e., gelatin) as part of the attachment surface. The synthetic collagen peptide-coated microcarriers would be an ideal replacement for existing products in animal product-free manufacturing protocols. Currently, three collagen-coated microcarriers, (a collagen-coated dextran bead [Cytodex 3] manufactured offshore and SoloHill's two gelatin-coated microcarriers) are the most extensively used microcarrier substrates in the industrial scale production of anchorage-dependent cells. As manufacturers of viral vaccines and other biologicals move toward complete animal product-free manufacturing conditions, a substrate containing collagen or gelatin will not be acceptable. Microcarriers with a synthetic collagen peptide - coated surface would provide an ideal replacement. The Phase II studies described here follow directly from the successes achieved in Phase I. The Phase II work plan is divided into three overall specific aims. Specific Aim I. To develop a microcarrier that has a synthetic collagen peptide on its surface. This microcarrier would be an animal product-free equivalent of (and in some applications a replacement for) the SoloHill gelatin-coated microcarriers. Specific Aim II. To develop a dextran microcarrier that has a synthetic collagen peptide on its surface. This microcarrier would be an animal product-free equivalent of (and a replacement for) the collagen-linked dextran microcarriers now manufactured and sold by a foreign competitor. Specific Aim IIl. To investigate the utility of additional microcarrier synthetic surface coatings as replacements of current products with porcine gelatin on the surface. Examples are modifications to the current synthetic collagen peptide and recombinant human collagen and gelatins.

Principal Investigator:

William J. Hillegas
7349732956
SOLOHILL@IC.NET

Business Contact:

Timothy Solomon
7349732956
SOLOHILL@IC.NET
Small Business Information at Submission:

Solohill Engineering, Inc.
Solohill Engineering, Inc. 4220 Varsity Dr, Ste A Ann Arbor, MI 48108

EIN/Tax ID: 382542305
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No