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A NOVEL MASS SPECTROMETER FOR DIRECT MIXTURE ANALYSIS.

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
17416
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
17416
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Southwest Sciences, Inc.
1570 Pacheco St. Suite E-11 Santa Fe, NM 87505-3993
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: Yes
 
Phase 1
Fiscal Year: 1992
Title: A NOVEL MASS SPECTROMETER FOR DIRECT MIXTURE ANALYSIS.
Agency: NSF
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE COMBINATION OF GAS CHROMATOGRAPHY WITH MASS SPECTROMETRY(GC/MS) PROVIDES THE BEST GENERAL PURPOSE ANALYTICAL INSTRUMENT FOR SENSITIVE CHARACTERIZATION OF COMPLEX MIXTURES. IT IS USED IN THE FIELDS OF CHEMISTRY, BIOLOGY, GEOCHEMISTRY, ENVIRONMENTAL SCIENCE AND FORENSICS. IN MOST CASES, THE GAS CHROMATOGRAPH SEPARATES THE STARTING MIXTURE INTO ITS CONSTITUENT COMPOUNDS PRIOR TO ANALYSIS BY THE MASSSPECTROMETER. THE SEPARATION STEP IS THE MOST TIME-CONSUMING PORTION OF THE ANALYSIS, OFTEN TAKING NEARLY AN HOUR, WHILE MASS ANALYSIS FOR EACH ELUTED COMPOUND IS COMPLETE IN A SECOND OR LESS. OUR INNOVATION PROVIDES A METHOD FOR THE DIRECT MASS SPECTROSCOPIC ANALYSIS OF MIXTURES (U.S. PATENT #5,015,848) AND CAN SPEED OVERALL ANALYSIS TIME BY REDUCING THE DEGREE OF CHROMATOGRAPHIC SEPARATION NEEDED. WE USE A NOVEL IONIZATION MODULATION SCHEME THAT INCREASES THE AMOUNT OF CHEMICALLY USEFUL INFORMATION OBTAINED FROM A MASS SPECTROMETER. THE SYSTEM IS AUTOMATED AND SUPPORTS COMPUTERIZED DECONVOLUTION OF THE RESULTANT TWO-DIMENSIONAL SPECTRA. THE PHASE I PROGRAM ADDRESSES OPTIMIZATION OF THE INSTRUMENTDESIGN BY MAXIMIZING THE DATA ACQUISITION RATE (WHILE MAINTAINING GOOD SIGNAL-TO-NOISE RATIOS OVER A LARGE DYNAMIC RANGE), DETERMINING THE LIMITS TO SENSITIVITY, DETERMINING THE OPTIMUM ELECTRON ENERGY RESOLUTION AND SELECTING THE BEST ALGORITHM FOR COMPUTERIZED DATA REDUCTION.

Principal Investigator:

Dr. David S. Bomse
Principal Research Scientist
5059841322

Business Contact:

Small Business Information at Submission:

Southwest Sciences Inc
1570 Pacheco St Suite E-11 Santa Fe, NM 87501

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No