The avian egg has been recognized by space biologists as an excellent, self-contained model for life-science research for more than a decade. more recently, birds have gained attention as a possible bioregenerative life-support system for space stations and lunar/mars missions. before the full… More

The specific innovation proposed is a fully-automated perfused cell-culture bioreactor system (laboratory in a cassette) tentatively named DYNACULT. Space Hardware Optimization Technology, Inc.,will incorporate several technical innovations into the integrated DYNACULT system. These include, but are… More

The specific innovation proposed, tentatively named ¿DYNASCOPE¿, is an innovative system of microscopy equipment capable of unique sample manipulation and real-time observation. A uniquely designed hollow microscope slide with high manufacturability offers an opportunity to study the effects… More

The specific innovation proposed, tentatively named ¿DYNASCOPE¿, is an innovative system of microscopy equipment capable of unique sample manipulation and real-time observation. A uniquely designed hollow microscope slide with high manufacturability offers an opportunity to study the effects… More

The specific innovation proposed is a fully-automated perfused cell-culture bioreactor system (laboratory in a cassette) tentatively named DYNACULT. Space Hardware Optimization Technology, Inc.,will incorporate several technical innovations into the integrated DYNACULT system. These include, but are… More

The specific innovation proposed, tentatively named ¿DYNASCOPE¿, is an innovative system of microscopy equipment capable of unique sample manipulation and real-time observation. A uniquely designed hollow microscope slide with high manufacturability offers an opportunity to study the effects… More

"This proposal addresses the activities associated with the development of the Modular Environmental Situational Awareness Technology (MESAT), which is intended as an important part of the United States' response to a terrorist attack using chemical orbiological weapons of mass destruction. The… More

The specific innovation proposed is a fully-automated perfused cell-culture bioreactor system (laboratory in a cassette) tentatively named DYNACULT. Space Hardware Optimization Technology, Inc.,will incorporate several technical innovations into the integrated DYNACULT system. These include, but are… More

The specific innovation proposed for continued research is a family of fully-automated (robotic) cell-culture systems, each a laboratory in a cassette, named collectively ?Multicult?. SHOT will incorporate several technical innovations, including options for gentle mixing of cell suspensions,… More

Macromolecules are crystallized for crystallography in ?screens? consisting of numerous (30-200) small volumes (2 ? 50 muL) of combinations with several (2-10) other solutes. Each combination is frequently over days or weeks to evaluate growth, if any, of crystals, thereby creating of repetitious,… More

The specific innovation proposed for continued research is a family of fully-automated (robotic) cell-culture systems, each a laboratory in a cassette, named collectively ?Multicult?. SHOT will incorporate several technical innovations, including options for gentle mixing of cell suspensions,… More

This proposal addresses the SHOT design concept and development path for a highly innovative,

Recent military activity reflects the importance of continued technological advancements for all products within the modern soldier''s arsenal. The U.S. must continue to invest in the development of products that not only provide quicker, better, fasterresults, but they must also be more robust and… More

This Small Business Innovation Research (SBIR) Phase I project proposes to develop the technology for the magnetic isolation of rare cancer cells from human blood. Various problems have been encountered in attempts to collect and identify cancer cells. Success will require processing large volumes… More

DESCRIPTION (provided by applicant): SHOT proposes to perform research leading to the implementation of technology for the magnetic isolation of hematopoietic stem cells from human umbilical cord blood and peripheral apheresis product cells. Bone marrow transplantation (BMT) is an established… More

DESCRIPTION (provided by applicant): Several aspects of health and medicinal research depend on the knowledge of macromolecular structures, the determination of which depends on a supply of high-quality crystals. Conditions for growing high-quality crystals are usually determined by expensive… More

SHOT proposes an innovative microfluidic device designed to effect a 2-dimensional resolution of a mixture of proteins based on isoelectric point (pI) and molecular weight. A novel approach is proposed to achieve 2-D-gel equivalence. The first dimension is to be immobilized isoelectric focusing, and… More

DESCRIPTION (provided by applicant): SHOT proposes research leading to the commercialization of technology for magnetic isolation of hematopoietic stem cells from human umbilical cord blood, bone marrow and peripheral apheresis product cells. Bone marrow transplantation (BMT) is an established… More

The Army currently uses fluorescent lighting that is large, heavy, extremely inefficient, and expensive to illuminate deployable shelters. Because the light fixtures can't be rolled up with the portable shelter, they must be individually removed and stowed separately for transport, further… More

The proposed innovation is a microfluidic device designed to effect a 2-dimensional resolution of a mixture of proteins based on isoelectric point (pI) and molecular weight (MW). The innovation performs tasks similar to those performed by 2-dimensional ("2-D") gel electrophoresis. To achieve… More

DESCRIPTION (provided by applicant): SHOT proposes research leading to a magnetic separation technology that will provide an increase in efficiency and yield of pancreatic islets of Langherhans isolated from donor pancreatic tissue. Pancreatic islet transplantation is a rapidly developing method of… More

Today's special operations soldier must pack over 75 pounds of gear through a wide range of environmental extremes. Those 75 pounds consist of mission essential electronic devices with 25 of those pounds consigned to onetime use batteries. For issues of stealth, stamina, and sustainment, it is… More

SHOTr proposes to design and develop an innovative data acquisition system with previously unavailable capabilities for use in the research and development of precision munitions by the United States defense community. This second generation on-board recorder (OBR-II) has highly advanced interface… More

The U.S. Government is a heavy user of concrete structures for below-grade facilities, waterway, and marine applications. High hydraulic permeability of the concrete in these structures produces water intrusion into protected areas and accelerated corrosion of structures beyond their useful limits,… More

The SHOT Shelter Lighting System (SLS) is an outstanding solution to the current problematic mobile fluorescent lighting fixtures. The SLS is a "systems approach" providing 700 lumens or more of adjustable illumination for battlefield shelters in a package that is robust, transportable and… More

The OBR-II feasibility research performed in Phase I confirmed our technical approach as the most suitable and appropriate design for the next generation data recorder. The SHOTr design will generate an innovative data acquisition system possessing previously unavailable capabilities for use in the… More

Mitigating Spatial Disorientation (SD) events is of particular interest to the military due to the severe repercussions of such events during flight or in general task performance for certain non-flight activities. Researchers have determined that these events could be mitigated by screening… More

A robotic sample management device and system for the exposure of biological and material specimens to heavy ion beams of the NASA Space Radiation Laboratory (NSRL) and other irradiation venues is proposed by SHOT, Inc. Full and efficient utilization of NSRL requires the automation of precise… More

Deployed stationary Marine facilities are equipped with a myriad of electronic communications and support equipment all requiring continuous power. Generally, power from portable generator units are not considered stable however, current inventories reflect a dire need for a versatile, robust… More

SHOT proposes to capitalize on our successful phase I effort of using electrophoresis as a novel coating mechanism for sealing concrete. Previous and ongoing research suggest that nanometer scale particles can be migrated into hardened cement paste resulting in dramatically lower hydraulic… More

SHOT's innovative design for a deeply buried hardened target fuze incorporates the use of a non-inertial proximity sensor as a solution to the shortcomings of existing accelerometer-based smart fuze designs. The proposed sensor is compact, relatively low power, and can easily be adapted to a wide… More

Current shipboard dishwashing systems are robust, dependable systems that unfortunately only perform specific dishwashing tasks. Scullery duties go beyond dishwashing and that is where the SHOT Automated Shipboard Dishwashing System can provide users a fully scoped complete system to include… More

A robotic sample management device and system for the exposure of biological and material specimens to heavy ion beams of the NASA Space Radiation Laboratory (NSRL) and other irradiation venues is proposed by SHOT, Inc. Full and efficient utilization of NSRL requires the automation of precise… More

This proposal contains SHOT's R&D concepts for a "Rapidly Configurable Modular Litter System for use in Aeromedical Transport." The Air Force is currently using the old pole and canvas style litter from pre WWII for aeromedical evacuation. A variety of medical treatment equipment is haphazardly… More

The SHOT Automated Shipboard Dishwashing System will provide users an automatic dishwashing and sortation system. The SHOT ASDS solution is a robust, modular drop-in solution that can either interface with existing dishwashing systems or can include a dishwasher/dryer tailored for the specific… More

Even today as a highly technical and advanced world civilization the physiology of deep sea fish and invertebrates continues to remain mysterious and poorly known. Past specimen containers fail to either have the size or volume needed or lack the robustness for high pressure containment or in many… More

DESCRIPTION (provided by applicant): SHOT, Inc., in collaboration with the University of Minnesota (UofM), Indiana University School of Medicine (IUSoM) and IKOtech LLC, proposes research leading to a magnetic separation technology that provides an improve ment in potency and yield of pancreatic… More

SHOT's innovative design for a deeply buried hardened target fuze incorporates the use of a non-inertial proximity sensor as a solution to the shortcomings of existing accelerometer -based smart fuze designs. The proposed sensor is compact, relatively low power, and can easily be adapted to a wide… More

Even today as a highly technical and advanced world civilization, the physiology of deep sea fish and invertebrates continues to remain mysterious and poorly known.  Past specimen containers fail to either have the size or volume needed or lack the robustness for high pressure containment of in… More

The proposed innovation is a "Microfluidic Multichannel Flow Cytometer." Several novel concepts are integrated to produce the final design, which is compatible with on-orbit operation from the standpoint of gravity-independence, low mass, low power requirement and automated operation. The unique… More

SHOT proposes an innovative vehicle arresting system designed for quick setup, unimpeded traffic flow, fast activation, and tremendous arresting power in a non-lethal manner. The proposed innovation uses cables, ground anchors, and an actuator mechanism combined in a novel way by SHOT's… More

The SHOT Explosion Proof Solid State Lighting Fixture (EPSSLF) is the "next generation" explosion proof fixture incorporating state-of-the-art, high output LED's. A properly sized LED light grid and associated power controller card will guarantee a long, maintenance free life at least 50 times… More

The Techshot Solid State Infrared Flare (SS IR Flare) will utilize existing high quality, commercial-off-the-shelf infrared LEDs to produce the required spectral output for use as a flare rocket providing illumination compatible with night vision gear. Powered by high current batteries, the… More

The Techshot LED Navigational Light Bulb (LED NAV LB) is the "next generation" light bulb incorporating state-of-the-art, robust solid state circuitry. A properly sized LED light grid will guarantee a long, maintenance free life at least 10 times longer than the current incandescent lamp. The… More

The Techshot Insect Vector Eradication, Control, Trapping, or Retrieval System (iVECTOR) trapping system employs a naturally seductive, ergonomically tailored system to attract and collect the maximum number of insect specimens for the given environment. The iVECTOR system is simple to erect,… More

Techshot, Inc. proposes continued research and development of an on-orbit cell counter culminating in a deliverable hand-held blood cell counter in the form of a "Microfluidic Multichannel Flow Cytometer". Crew health monitoring, the Human Research Program and research in Fundamental Biology will… More

The proposed "Observation platform for dynamic biomedical and biotechnology experiments using the ISS Light Microscopy Module" consists of a platen sized to fit the stage of NASA's Light Microscopy Module (LMM) on the International Space Station (ISS). At the heart of the innovation is a small… More

The Techshot Aeromedical Stabilization and Evacuation System (ASES) solution consists of three subsystems including a Patient Support Platform (PSP), a Comfort Mat System (CMS) and a detachable Aeromedical Equipment Module (AEM). The ASES system provides a stabilization and traction platform… More

Techshot proposes an innovative solution to provide low cost time synchronized telemetry, flow diagnostics, and data collection to support small-scale wind tunnel free drop testing. A key feature is a synchronization technique for multiple data sources including high speed cameras to support proper… More

Techshot's ideal solution for a multi axis vibration damping insert (MVDI) will provide the Navy with a functional system to reduce crew member fatigue and injuries due to mid to high frequency propeller vibrations transmitted through the current seat cushion as well as reduction of hot spots… More

This project was funded as a Phase I contract by the NCI Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Program in response to funding announcement number 272 "Point of Care Analysis of Circulating Tumor Cells for Cancer Diagnostics, Prognosis, and… More

Deployed stationary Marine facilities are equipped with a myriad of electronic-communications equipment all requiring continuous power. Generally, power from portable generator units are not considered stable however, current inventories reflect a dire need for a versatile, robust uninterrupted… More

DESCRIPTION (provided by applicant): The broad, long-term objective of the proposed project Electrical System for Rapid Bacterial Cultures is to develop an automated electrical impedance analyzer for measuring bacterial growth in contaminated blood. Thepurpose of the System is to hasten the time… More

The objective of the research is the completion of an observation platform for the ISS Light Microscopy Module (LMM) as it currently resides on the U.S. Fluids Integration Rack (FIR). In its current configuration the LMM accommodates a Contained Bubble Experiment, and it has no substage illuminator… More

Traditionally spaceflight life science experiments require the return of samples to earth for analysis, which is frequently a challenge to the success of investigations. Even with more analytical instruments on ISS, conditions do not facilitate the transfer of liquid samples from experimental… More

Techshot, Inc. proposes to develop a Multi-specimen Variable-G Facility (MVF) for life and microgravity sciences research. The MVF incorporates a generic multi-specimen sample holder which can be accessed on-orbit, allowing data to be obtained in real-time. Candidate specimens accommodated by the… More

The Techshot Autonomous Battery Management System (ABMS) is the ideal solution to the stored battery problems experienced today. The Techshot ABMS reduces operating costs via an automated battery management system. The ABMS is suitable for both smart and dumb rechargeable batteries, as well as a… More

Techshot proposes to improve the isolation and immunoselection of mesenchymal stem cells from adipose tissue using Quadrupole Magnetic flow Sorting (QMS). This separator technology sorts magnetically labeled cells at high speed and is capable of processing large volumes of tissue such as… More

The ASES concept, consists of three subsystems including a Patient Support Platform (PSP), a Comfort Mat System (CMS) and a detachable Aeromedical Equipment Module (AEM). This system provides a stabilization and traction platform solution for aeromedical evacuation with comfort mat subsystem using… More

With retirement of the space shuttle program, microgravity researchers can no longer count on bringing experiment samples back to earth for post-flight analysis. Locker-sized processing facilities, which were typically transported up to and down from the International Space Station during the… More

The Multi-specimen Variable-G Facility (MVF) is a single locker sized centrifuge facility for life and microgravity sciences research on the International Space Station. The MVF is a rear breather EXPRESS Rack payload that leverages many of the existing subsystems of flight proven (STS-108) Avian… More

Designation of the International Space Station (ISS) as a National Laboratory creates exciting opportunities for a broad spectrum of researchers to take advantage of ISS's unique space attributes and scientific research facilities. The Light Microscopy Module (LMM), which was developed and is… More

Cellular therapies are rapidly moving toward widespread clinical application in cancer treatment, autoimmune disease control and trauma recovery. Human adipose tissue, an available waste product from reconstructive and plastic surgery, is becoming a most popular source of adult stem cells, which are… More