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Cassette Based Robotic Multiple Cell Culture System

Award Information

National Aeronautics and Space Administration
Award ID:
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
7200 Highway 150 GREENVILLE, IN 47124-9515
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 2
Fiscal Year: 2002
Title: Cassette Based Robotic Multiple Cell Culture System
Agency: NASA
Contract: NAS9-02081
Award Amount: $599,982.00


The specific innovation proposed for continued research is a family of fully-automated (robotic) cell-culture systems, each a laboratory in a cassette, named collectively ?Multicult?. SHOT will incorporate several technical innovations, including options for gentle mixing of cell suspensions, transparent monolayer culture surfaces, control of inertial load (?g-level?) by rotation within the cassette, pH monitoring, adding fresh medium or fixatives with immediate mixing, and real-time imaging of cells in transparent containers. SHOT will perform research leading to (1) a cassette-based rotating plate for exposing 8 cultures of suspended cells to acceleration levels from 1 to 5 g while facilitating fluid additions and balancing out all forces other than centrifugal and gravity vectors, (2) a curved-wall transparent culture vessel for centrifugal studies of adherent cells, (3) a miniaturized non-invasive pH reader, (4) a compact video microscope, (5) a control-and-data network of embedded processors, and (6) a deliverable prototype cassette-based Multicult system incorporating these features for the sponsor. SHOT will use the results of this research to develop, in addition to a cell culture capability for space flight, marketable instruments based on its pH reader, centrifugal culture plates and autonomously controlled Multicults.

Principal Investigator:

Dr Paul Todd
Chief Scientist

Business Contact:

Mark S. Deuser
President & CEO
Small Business Information at Submission:

Space Hardware Optimization Technology
7200 Highway 150 Greenville, IN 47124

EIN/Tax ID: 351784668
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No