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Microfluidic Analytical Separator for Proteomics

Award Information

Agency:
National Aeronautics and Space Administration
Branch:
N/A
Award ID:
68496
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
033429
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
TECHSHOT, INC.
7200 Highway 150 GREENVILLE, IN 47124-9515
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2005
Title: Microfluidic Analytical Separator for Proteomics
Agency: NASA
Contract: NNJ05JA05C
Award Amount: $599,947.00
 

Abstract:

The proposed innovation is a microfluidic device designed to effect a 2-dimensional resolution of a mixture of proteins based on isoelectric point (pI) and molecular weight (MW). The innovation performs tasks similar to those performed by 2-dimensional ("2-D") gel electrophoresis. To achieve 2-D-gel equivalence with minimal complications and maximum exploitation of the advantages provided by microfluidics a novel approach is proposed. In this approach the user dissolves or mixes a sample to be tested for proteins into a sample buffer and injects this into a plastic card consisting of microfluidic channels and electrodes. The card is inserted into a compact "reader" (small enough for space flight) that, within four hours, electronically reports the abundance of each protein detected. In Phase II research SHOT will (1) establish fabrication parameters for the card and manufacture prototypes, (2) build a breadboard reader and (3) test the Microfluidic Analytical Separator using mixed protein solutions. The innovation is useful in detecting specific protein ratio changes in blood or plasma, in extracts of experimental organisms subjected to varying environmental conditions, and in the medium-resolution high-throughput screening of pharmaceutical agents.

Principal Investigator:

Paul W. Todd
8129239591
ptodd@SHOT.com

Business Contact:

Mark S. Deuser
Business Official
8129239591
mdeuser@SHOT.com
Small Business Information at Submission:

Space Hardware Optimization Technology
7200 Highway 150 Greenville, IN 47124

EIN/Tax ID: 351784668
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No