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PROTEIN KINASE C THERAPEUTIC DEVELOPMENTAL TOOLS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7172
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7172
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Sphinx Pharmaceuticals
Box 52330, 4 University Place Durham, NC 27717
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: PROTEIN KINASE C THERAPEUTIC DEVELOPMENTAL TOOLS
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE LONG-TERM GOALS OF THIS RESEARCH ARE TO CONTRIBUTE TO ANUNDERSTANDING OF THE ROLE OF PROTEIN KINASE C IN NEOPLASTIC TRANSFORMATION AND CELLULAR REGULATION BY SIGNAL TRANSDUCTION PROCESSES. PROTEIN KINASE C FUNCTIONS TO TRANSDUCE SN-1,2-DIACYLGLYCEROL SECOND MESSENGERS, PRODUCED IN RESPONSE TO GROWTH FACTORS, NEUROTRANSMITTERS, HORMONES, AND SOME ONCOGENE PRODUCTS, AND IT IS THE RECEPTOR OF TUMOR PROMOTERS. THE HYPOTHESIS THAT PROTEIN KINASE C MAY BE THE TARGET OF ANTITUMOR AND OTHER THERAPEUTIC AGENTS WILL BE TESTED BY: (1) REFINING MIXED MICELLAR-ASSAY METHODS TO SCREEN FOR PROTEIN KINASE C AGONISTS AND ANTAGONISTS AND THEIR MECHANISM OF ACTION; (2) APPLYING THESE METHODS TO THEPILOT TESTING OF 500 COMPOUNDS, SUBMITTED TO NCI, THAT POSSESS ANTITUMOR ACTIVITY; AND (3) REFINING METHODS OF SN-1,2-DIACYLGLYCEROL QUANTITATION AND APPLYING THEM TO NORMAL AND DISEASED TISSUES. THESE STUDIES ARE DIRECTLY RELATED TO ONCOGENESIS AND ANTITUMOR THERAPEUTIC DEVELOPMENT PROGRAMS. IMPORTANTLY, SUCH ANALYSES WILL ESTABLISH THE DESIRABILITY OF BIOCHEMICALPRESCREENS OF COMPOUNDS SUBMITTED TO THE NCI AND ELUCIDATE CAUSATIVE AGENTS OF CELLULAR TRANSFORMATION. THE CENTRAL INVOLVEMENT OF PROTEIN KINASE C AND SN-1,2-DIACYLGLYCEROL SECOND MESSENGERS IS RELEVANT TO ENDOCRINOLOGY, NEUROLOGY, GROWTH, DIFFERENTIATION, DEVELOPMENT, ARTHRITIS AND OTHER INFLAMMATORY RESPONSES, SMOOTH MUSCLE CONTRACTION, PSORIASIS, DIABETES, AND OTHER HUMAN CONDITIONS.

Principal Investigator:

Carson r loomis
9194898473

Business Contact:

Small Business Information at Submission:

Sphinx Corp
3628 Carlisle Dr Durham, NC 27707

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No