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Elimination of Infections in External Fixation Devices

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
21942
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
21942
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Spire Corporation
One Patriots Park Bedford, MA 01730-2396
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1993
Title: Elimination of Infections in External Fixation Devices
Agency: HHS
Contract: N/A
Award Amount: $49,940.00
 

Abstract:

A research plan is described to establish the feasibility of using ion beam processes to reduce or eliminate pin tract infection in external fixation devices. A process will be developed for producing bacteriostatic, biocompatible surfaces. Anti-bacterial properties will be evaluated via in vitro microbial challenge tests; cytotoxicity and systemic injection tests will be used to screen biocompatibility. The in vivo efficacy of the treatment will be evaluated by treating actual pins, implanting them into tibiae of domestic sheep and comparing their performance to control pins. The pins will be retrieved and examined for bacterial colonization of several bacterial strains. These in vivo tests will lead the Phase I program into a Phase II study; Phase II will involve further analytical and bench-top testing as well as more comprehensive animal studies and/or clinical trials.

Principal Investigator:

Piran Sioshansi
6172756000

Business Contact:

Small Business Information at Submission:

Spire Corp.
One Patriots Park Bedford, MA 01730

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No