USA flag logo/image

An Official Website of the United States Government

Efficacy of Thin HA Coatings Produced by a Novel Process

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
54382
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
1R43DE013450-01A2
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Spire Corporation
One Patriots Park Bedford, MA 01730-2396
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2004
Title: Efficacy of Thin HA Coatings Produced by a Novel Process
Agency: HHS
Contract: 2R44DE013450-02A1
Award Amount: $943,045.00
 

Abstract:

DESCRIPTION: (provided by the applicant) This project is developing a new generation of calcium phosphate coatings for dental implants, in which film crystallinity is optimized for enhanced bioactivity and osseointegration. Phase I examined the hypothesis that optimal crystallinity leads to more rapid and stronger device fixation. Film crystallinities ranging from 30-90% were produced by a novel, low temperature deposition method and evaluated in a small animal model (rat). It was found that the ideal range was between 50-70% crystalline. These coatings provided bone-device integration compared to conventional plasma spray coatings. The purpose of the Phase II program is to further evaluate and demonstrate the advantage of calcium phosphate coatings with optimized crystallinity, as defined in Phase I. Both early and long-term bone response will be assessed in a large animal (canine) model, both prior to and after prosthesis loading. The desire to introduce this innovative technology to the field of dental implantology is based on two primary advantages of the process over existing technology used to apply HA coatings to implants. First, the chemical composition and crystallinity of the applied coating can be precisely controlled over a wide range of values, without the need for post deposition annealing. Second, the HA coatings can be deposited at low temperature as thin films from 1 to 5 mu/m thick, much thinner than coatings applied using plasma spray technology. Thinner coatings can provide a higher interfacial strength and better resistance than thicker plasma spray coatings.

Principal Investigator:

Eric J. Tobin
7812756000
ETOBIN@SPIRECORP.COM

Business Contact:

Mark Little
7812756000
MLITTLE@SPIRECORP.COM
Small Business Information at Submission:

SPIRE CORPORATION
SPIRE CORPORATION 1 PATRIOTS PARK BEDFORD, MA 01730

EIN/Tax ID: 042457335
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No