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Non-invasive Blood-glucose Monitor using Terahertz Radiation

Award Information

Department of Defense
Office of the Secretary of Defense
Award ID:
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Spire Corporation
One Patriots Park Bedford, MA 01730-2396
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2004
Title: Non-invasive Blood-glucose Monitor using Terahertz Radiation
Agency / Branch: DOD / OSD
Contract: W81XWH-04-C-0109
Award Amount: $99,677.00


This Phase I SBIR proposal describes a research program to determine feasibility for using terahertz radiation to non-invasively monitor metabolic analytes such as glucose. Non-invasive monitoring is important for determining general physiological activity and health, and needed by diabetics for painless, rapid glucose measurement. Mid-infrared and far-infrared monitoring has been extensively explored, but after many years of research, no reliable instrument is available. Infrared glucose concentration data reliability is poor due to strong radiation scattering and overlapping signals arising from blood components that maski glucose signals. Based on published data, improved molecular discrimination may occur in the terahertz spectral region, where DNA and organic-molecule resonant absorption spectra dominate, where photon scattering is reduced, and where a new generation of miniature cascade-lasers is under development. Phase I will investigate terahertz absorption spectra in glucose-containing phantoms simulating blood, and in purchased laboratory blood solutions with known glucose concentrations. The measurements will be performed at the Brookhaven synchrotron source, using an FTIR spectrometer and terahertz radiation detector. The proposed project dovetails with a companion program to develop a miniature terahertz cascade-laser source at Spire Biomedical. Phase II will include tissue-measurements and develop a portable, non-invasive monitoring system using the terahertz cascade-laser.

Principal Investigator:

Kurt J. Linden
Senior Scientist

Business Contact:

Mark C. Little
CEO, Spire Biomedical, In
Small Business Information at Submission:

One Patriots Park Bedford, MA 01730

EIN/Tax ID: 042457335
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No