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ANALGESICS FOR CHRONIC PAIN TREATMENT IN THE ELDERLY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
54150
Program Year/Program:
2001 / STTR
Agency Tracking Number:
1R41AG018196-01A1
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ST. CHARLES PHARMACEUTICALS
650 Poydras St, Suite 2830 New Orleans, LA 70130
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: ANALGESICS FOR CHRONIC PAIN TREATMENT IN THE ELDERLY
Agency: HHS
Contract: PHS2001-2
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION(adapted from applicant's abstract): Acetaminophen, a nonsteroidal anti-inflammatory drug (NSAID), is widely used for treatment of pain and/or fever in the elderly. This dual action is sometimes contraindicated. In many instances pain needs to be controlled without masking the symptomatic fever (e.g., postoperative period). Acetaminophen can also cause hepatotoxicity, particularly after ingestion of large doses or chronic use of smaller doses (especially in the elderly or when liver function is affected) that can lead to death. Therefore, there is a need for new more selective compounds with greater pharmacological potency and devoid of hepatotoxic or antipyretic effect. We are exploring a series of new proprietary derivatives of acetaminophen. In preliminary studies, one of these compounds (SCP-1) demonstrated high analgesic activity free from antipyretic activity and hepatotoxicity. In this STTR project we propose to further characterize SCP-1 and compare biological properties with acetaminophen. We will also explore combinations of SCP-1 with morphine (and with other pain relievers) to confirm preliminary studies indicating a synergistic effect of this combination. The Phase I experiments will help us ascertain the legitimacy of SCP-1 as a lead candidate drug worthy of further development and testing in Phase II for the treatment of chronic and post-operative pain in the elderly.

Principal Investigator:

Kenneth W. Narducy
4082238748
KNARDUCY@MSN.COM

Business Contact:


5048611664
KNARDUCY@MSN.COM
Small Business Information at Submission:

ST CHARLES PHARMACEUTICALS
478 BROADWAY ST NEW ORLEANS, LA 70118-3553 NEW ORLEANS, LA 70118

EIN/Tax ID: 721438669
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
LOUISIANA STATE UNIVERSITY
NEW YORK EYE & EAR INFIRMARY
NEW ORLEANS, LA 70122
RI Type: Nonprofit college or university