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DEVELOPMENT OF NOVEL THERAPEUTICS FOR POSTSURGICAL PAIN

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
61127
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
NS038358
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ST. CHARLES PHARMACEUTICALS
650 Poydras St, Suite 2830 New Orleans, LA 70130
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2002
Title: DEVELOPMENT OF NOVEL THERAPEUTICS FOR POSTSURGICAL PAIN
Agency: HHS
Contract: 2R44NS038358-02
Award Amount: $835,120.00
 

Abstract:

Acetaminophen and NSAIDs have been used routinely for treatment of pain and/or fever. This dual action is sometimes contraindicated. In many instances, pain needs to be controlled without masking symptomatic fever (e.g., during the postoperative period). These drugs can cause hepatotoxicity, particularly after ingestion of large doses or from chronic use (especially when liver function has been compromised), which can lead to death. We are exploring a series of new and proprietary derivatives of acetaminophen that have good pharmacological potency and little hepatotoxic, nephrotoxic, or antipyretic effects. In preliminary studies, the initial compounds demonstrated high analgesic activity free from antipyretic activity and hepatotoxicity. In Phase I, we further characterized these initial compounds and several other analogs/derivatives and identified a lead candidate drug. We will further test and develop this drug in Phase II for treating postoperative pain and for other analgesic treatments where acetaminophen is contraindicated. We will also use a combination of in vitro and in vivo models to evaluate additional analogs and derivatives of the Phase I lead candidate drug. We will choose second-generation candidates based on efficacy, pharmacokinetic, and toxicity evaluations.

Principal Investigator:

Kenneth W. Narducy
4082238748
KNARDUCY@MSN.COM

Business Contact:

Kenneth Narducy
5048611664
KNARDUCY@MSN.COM
Small Business Information at Submission:

ST CHARLES PHARMACEUTICALS
ST CHARLES PHARMACEUTICALS 478 BROADWAY ST NEW ORLEANS, LA 70118

EIN/Tax ID: 721438669
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No