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FIBER OPTICS, FIBER OPTIC CHEMICAL SENSORS (FOCS), AND FLUORESCENCE…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
2963
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
2963
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
St&e Inc
1233 Quarry Ln - Ste 145 Pleasanton, CA 94566
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: FIBER OPTICS, FIBER OPTIC CHEMICAL SENSORS (FOCS), AND FLUORESCENCE SPECTROSCOPY WERE COMBINED TO FORM THE NEW TECHNIQUE OF REMOTE FIBER FLUORIMETRY.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

FIBER OPTICS, FIBER OPTIC CHEMICAL SENSORS (FOCS), AND FLUORESCENCE SPECTROSCOPY WERE COMBINED TO FORM THE NEW TECHNIQUE OF REMOTE FIBER FLUORIMETRY. THIS METHODOLOGY PERMITS DEVELOPMENT OF DUCTILE PROBES TO MEASURE PHYSIOLOGICAL PARAMETERS OF INTEREST TO THE GASTROENTEROLOGIST. THE KEY TO THIS CONCEPT IS THE FOCS, A FIBER TERMINATION WITH PRESELECTED CHEMICAL OR PHYSICAL PROPERTIES. THIS IS ATTACHED TO THE DISTAL END OF THE FIBER SO THAT SPECIFIC IN VIVO AND IN VITRO CLINICAL MEASUREMENTS CAN BE MADE. A SINGLE FIBER IS USED FOR BOTH EXCITATION AND FOR COLLECTION OF THE FLUORESCENT SIGNAL, KEEPING THE OBJECTIVE IS TO MAKE A FOCS SUITABLE FOR MEASUREMENT OF BILE ACIDS. A HYDROXYSTEROID DEHYDROGENASE/NAD SYSTEM WILL BE USED AS THE SPECIFIC INDICATOR. THIS WILL BE IMMOBILIZED ONTO THE FIBER. THE FORMATION OF NADH IN THE PRESENCE OF BILE ACIDS WILL BE MONITORED BY THE FLUORESCENCE EMISSION AT 480 NM USING 340 NM EXCITATION. THE FOCS WILL BE TESTED IN THE LABORATORY USING SYNTHETIC BILE SYSTEMS.

Principal Investigator:

Stanley m. klainer
PRINCIPAL INVESTIGATOR
4154498516

Business Contact:

Small Business Information at Submission:

St&e Technical Services, Inc.
1791 Barcelona Street Livermore, CA 94550

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No