Numerous compounds with known or suspected antineoplastic activity have been synthesized, which frequently are too insoluble or unstable in aqueous media for parenteral administration. some of these compounds are not sufficiently soluble even with ph adjustment or minor solvent reformulations, and… More

In 1984 an nih consensus conference recommended community based cholesterol screening programs to evaluate hypercholesterolemia in the context of its association with increased heart attacks. there is a developing literature that the apolipoproteins a-1 and b are better measures of risk than hdl and… More

This project will further develop two methods for incorporating antibiotics into surface coatings and will also compare the relative utility of the two methods, directincorporation of the antibiotic into the coating at manufacture vs. imbibition of the antibiotic into the coating just prior to… More

The majority of aids patients, when first examined, have symptoms of opportunistic infections, the most common being pneumocystis carinii. the high mortality rate defines a need for treatment and prophylaxis of this and other life- threatening opportunistic infections. pentamidine has a role to… More

We will develop and evaluate polymer coatings containing anticoagulant drugs. these polymers, when applied to the surface of a prosthesis that comes in contact with blood, renders the device nonthrombogenic. thus frequently encountered clinical complications related to thrombus formation are… More