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Soluble Galcer Analogs as Anti-HIV Therapeutic Agents

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29587
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
29587
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Steroids Ltd.
2201 West Campbell Park Dr Chicago, IL 60612
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1995
Title: Soluble Galcer Analogs as Anti-HIV Therapeutic Agents
Agency: HHS
Contract: 1 R43 MH53685-01,
Award Amount: $65,700.00
 

Abstract:

Galactosyl ceramide (GalCer) acts as an alternative receptor for HIV in CD4 negative cells throughto the HIV envelope glycoprotein gp 120. The design and synthesis of GalCer analogs capable of bindiblocking its interaction with GalCer is potentially a powerful therapeutic approach against HIV infesynthesize four GalCer analogs, namely, 1-O-(beta-D-galactopyranosyl)-L-threo-dihydrosphingosine, 1-galactopyranosyl)-L-erythro-dihydrosphingosine, 1-O-(beta-D- galactopyranosyl)-D-threo-dihydrosphing(beta-D- galactopyranosyl)-D-erythro-dihydrosphingosine. These four compounds were selected becausethe structural components essential for the binding to gp 120, and the lack of the fatty acid on theconsiderably their solubility in water. The ability of these analogs to bind to HIV gp 120 will be ausing HPTLC binding assays on 1251-labeled gp 120, and their ability to inhibit HIV infection will bnegative cells (e.g. SK-N-MC). We plan to study an alternative therapeutic approach, conjugating thecytotoxic compounds, and using them as targeting agents to deliver toxins selectively to HIV-infecte

Principal Investigator:

Liang Guo
31221

Business Contact:

Small Business Information at Submission:

Steroids, Ltd.
Chicago Technology Park 2201 W. Campbell Park Drive Chicago, IL 60612

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No