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THE PRACTICAL APPLICATION OF THE REGULATION OF A DISTINGUISHABLE PORCINE…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4850
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4850
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Sullivan Veterinary Clinic
713 E Jackson Sullivan, IL 61951
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: THE PRACTICAL APPLICATION OF THE REGULATION OF A DISTINGUISHABLE PORCINE BLASTOMERE, CAUSING IT TO DIFFERENTIATE INTO THE INNER CELL MASS, HENCE THE OFFSPRING,WILL BE INVESTIGATED.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE PRACTICAL APPLICATION OF THE REGULATION OF A DISTINGUISHABLE PORCINE BLASTOMERE, CAUSING IT TO DIFFERENTIATE INTO THE INNER CELL MASS, HENCE THE OFFSPRING,WILL BE INVESTIGATED. PORCINE BLASTOMERES WILL BE OBTAINED BY MICRODISSECTION OF AN 8-CELL EMBRYO RECOVERED FROM A PURERED BREED AND THEN INTERMINGLED WITH BLASTOMERES OF A 4-CELLEMBRYO RECOVERED FROM A PURE WHITE BREED. THE DEVELOPMENT OF THE RESULTING CHIMAERIC EMBRYOS WILL BE MONITORED AT TERM(1) AFTER IN UTERO TRANSPLANTATION, AND (2) AFTER IN UTERO TRANSPLANTATION FOLLOWING A TEMPORARY CULTURE PERIOD IN THE OVIDUCT OF A PORCINE RECIPIENT. FIFTY PERCENT OF THE EMBRYOS CULTURED IN OVIDUCTS WILL BE PROTECTED WITH A 1.0 PERCENT AGAR COATING. RED PIGLETS BORN ARE ASSUMED TO BE TWINS ORIGINATING FROM THE 8-CELL EMBRYOS. PIGLETS BORN WHITE OR SANDY COLORED WILL BE RECORDED AS EITHER A PURE WHITE OR A CHIMAERIC PIGLET. ONE-EIGHTH PORCINE BLASTOMERESARE EXPECTED TO DEVELOP SIMILAR TO ONE-EIGHTH BLASTOMERES OFOTHER SPECIES. SOLVING THE TECHNICAL PROBLEMS OF DEVELOP- MENT IN VIVO OF ONE-EIGHTH PORCINE BLASTOMERES AND THEIR REGULATION, RESULTING IN DISTINGUISHABLE OFFSPRING, WILL INCREASE THE PRACTICAL USE OF EMBRYO TRANSFER IN THE COMMERCIAL SWINE INDUSTRY.

Principal Investigator:

Jason e james
PRINCIPAL INVESTIGATOR
2177288356

Business Contact:

Small Business Information at Submission:

Sullivan Veterinary Clinic
713 East Jackson Sullivan, IL 61951

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No