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Company Information:

Company Name: SYMBIOTECH, INC.
City: WALLINGFORD
State: CT
Zip+4: 06492
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Website URL: N/A
Phone: (203) 949-2766

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $3,210,975.00 45
SBIR Phase II $6,776,186.00 12

Award List:

ACCESS: A COMMUNICATING AND COOPERATING EXPERT SYSTEMS SYSTEM

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Dr Robert C Paslay
Award Amount: $50,000.00

DESENSITIZING CARBONACEOUS ADSORBENTS TO THE EFFECTS OF HUMIDITY

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Edward M Davis
Award Amount: $50,000.00

CHEMILUMINESCENT LABELS FOR POLYNUCLEOTIDES ELECTROPHORETICALLY SEPARATED IN AGAROSE GELS

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr Edward M Davis
Award Amount: $50,000.00

CHEMILUMINESCENT LABELS FOR POLYNUCLEOTIDES ELECTROPHORETICALLY SEPARATED IN AGAROSE GELS

Award Year / Program / Phase: 1988 / SBIR / Phase II
Agency: DOE
Principal Investigator: Dr Edward M Davis
Award Amount: $499,000.00
Abstract:
This project is to develop a nonradioactive method for labeling genetic materials. a light-emitting chemical reaction (chemiluminescence) will be employed as a label. chemiluminescence, owing to its high sensitivity, simplicity, and safety, provides an alternative to radioisotopes. this new labeling… More

MICRO - EXTRACTION DEVELOPMENT FOR DRUG ASSAY

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00
Abstract:
The interface between two contiguous, immiscible liquid phases can be established within the micropores of a new type of polymeric membrane. these kinds of membranes in theform of tiny hollow fibers will be investigated for conducting liquid-liquid extraction as a first purification stage in the… More

A DISTRIBUTED ARTIFICIAL INTELLIGENCE REPRESENTATION LANGUAGE LANGUAGE

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: NASA
Principal Investigator: Dr Bruce H Cottman
Award Amount: $50,000.00

A DISTRIBUTED ARTIFICIAL INTELLIGENCE REPRESENTATION LANGUAGE LANGUAGE

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency: NASA
Principal Investigator: Dr Bruce H Cottman
Award Amount: $495,508.00
Abstract:
The next generation of artificial intelligence development environments must be able to incorporate a wide range of representation and reasoning technologies in a general framework. we are proposing the development of a taxonomic and descriptive representation language language (rll). a rll that can… More

DESENSITIZING CARBONACEOUS ADSORBENTS TO THE EFFECTS OF HUMIDITY

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: Edward M Davis
Award Amount: $371,032.00
Abstract:
This project will develop treatments to remove and modify surface oxygen compounds on carbon which bind water, thereby interfering with the adsorption of weakly adsorbing substances. adsorbent carbons and asc whetlerites will be prepared and treated by various methods to render them hydrophobic.… More

ACCESS: A COMMUNICATING AND COOPERATING EXPERT SYSTEMS SYSTEM

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: Dr Robert C Paslay
Award Amount: $538,814.00
Abstract:
The intent of this project is to provide a software environment which will allow immediate implementation of a variety of cooperating expert system paradigms. the environment, referred to as access, will be designed to be expert system representation independent, be portable to any hardware which… More

BIODEGRADATION OF HEAVY HYDROCARBONS

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Dr Edward M Davis
Award Amount: $55,573.00

BIODEGRADATION OF HEAVY HYDROCARBONS

Award Year / Program / Phase: 1990 / SBIR / Phase II
Agency / Branch: DOD / NAVY
Principal Investigator: Dr Edward M Davis
Award Amount: $490,100.00
Abstract:
Surfactants and enzymes which play key roles in the degradation of heavy hydrocarbons by microorganisms will be produced, purified and characterized. anaerobic and aerobic cultures of a number of microorganisms will be investigated as pure and as mixed cultures. key variables and parameters… More

AN EXTENSIBLE ARCHITECTURE FOR INTEGRATING DISTRIBUTED HETEROGENEOUS DATABASE SYSTEMS

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Dr Bruce H Cottman
Award Amount: $50,000.00
Abstract:
In today's rapidly changing and highly competitive environment, unimpeded access to information is essential for an organization's growth and survival. optimal information access requires full, transparent integration of available information resources. unfortunately, information resources are… More

PREPARATION OF PLASMA BY FILTRATION FOR ANALYSIS

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Pramod Rao
Award Amount: $49,826.00

METAAGENTS: A FRAMEWORK FOR INTELLIGENT DISTRIBUTED SYSTEMS

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: NASA
Principal Investigator:
Award Amount: $50,000.00
Abstract:
An intelligent distributed system presents significant integration and concurrency control problems. however, the tools that are currently available for distributed systems development in the areas of heterogeneous system integration and multiple process control are inadequate. an application that… More

SOUTHERN BLOTTING FOLLOWING CAPILLARY ELECTROPHORESIS

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: HHS
Principal Investigator: Davis, Edward M , Principal Investigator
Award Amount: $47,241.00
Abstract:
Capillary electrophoresis is becoming an important analytical tool. recent results show that dna sequencing can be performed with capillary gel electrophoresis. to further increase the utility of this analytical procedure, we will develop a new process for transferring dna and other analytes to… More

INTEGRATING AND COORDINATING INTELLIGENT PLANNING AND SCHEDULING TOOLS

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: NASA
Principal Investigator:
Award Amount: $49,968.00

PREPARATION OF PLASMA BY FILTRATION FOR ANALYSIS

Award Year / Program / Phase: 1992 / SBIR / Phase II
Agency: HHS
Principal Investigator: Pramod Rao
Award Amount: $488,185.00
Abstract:
There is a great need to develop new techniques for preparing blood samples. in clinical laboratories, preparing plasma for analysis requires few skills and is oneof the dirtiest and potentially dangerous tasks a technicianfaces. because centrifugation is a part of the problem, this project seeks to… More

NEW POLYMERS FOR AQUEOUS TWO-PHASE EXTRACTION SYSTEMS

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: NSF
Principal Investigator: Edward M Davis , President
Award Amount: $49,611.00
Abstract:
Aqueous two-phase extraction (atpe) is a mild procedure for isolating cells, cellular organelles, and biologically produced macromolecules such as enzymes. for small scale separations, atpe is most economical; however, due to the cost of polymers used in the extraction systems (e.g., dextran) costs… More

CHEMILUMINESCENT LABELS FOR VISUALIZATION OF DNA IN GELS

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kathryn E Matera
Award Amount: $50,000.00
Abstract:
The objectives are to develop novel chemiluminescent catalysts to enable visualization of oligonucleotides directly in electrophoretic gels. presently, streptavidin-horseradish peroxidase (mw greater than or equal to 100,000) can be employed to label biotinylated dna in agarose gels, with a… More

Biodegradation of Ordnance Ingredients by the White Rot Fungus

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Wafaa M, Mahmoud, Ph.d.
Award Amount: $50,000.00
Abstract:
1Critical experiments will be conducted to investigate the feasibility of using the white rot fungus, Phanerochaete Chrysosporium, and its enzymes for biotreatment of chemical waste arising from ordnance manufacture as well as for bioremediation of environmental contamination by ordnance chemicals.… More

Integrated Enterprise Product/Process Design System

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Robert C. Paslay
Award Amount: $49,068.00
Abstract:
One of the major goals that manufacturing institutions in the United States must achieve in order to be competitive in the world marketplace is getting higher quality products to market faster and cheaper. To accomplish this, they must leverage technologies, both new and old, to their fullest… More

IMPROVED RECOVERY OF ANTI-CANCER ANTIBIOTICS

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael J Malavasic
Award Amount: $50,000.00
Abstract:
Many anti-cancer drugs are high insoluble in aqueous media and difficult to recover from microbial and plant cells where they are produced. we will investigage a novel separation/purification approach for these systems. the method is simple and gentle and is applicable, in principle, to cells while… More

CELL-TARGETED BINARY ANTICANCER AGENTS

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kathryn M Matera
Award Amount: $49,516.00
Abstract:
A novel method for targeting cancerous tissue using non-toxic components will be developed. a binary system comprised of two catalytic components which act synergistically is targeted to a diseased cell. the juxtaposition of these components on the cell surface causes the production of intermediates… More

INTEGRATING AND COORDINATING INTELLIGENT PLANNING AND SCHEDULING TOOLS

Award Year / Program / Phase: 1992 / SBIR / Phase II
Agency: NASA
Principal Investigator:
Award Amount: $499,016.00

CYANIDE POISONING PROPHYLACTICS

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Edward M. Davis
Award Amount: $50,000.00

CYANIDE POISONING PROPHYLACTICS

Award Year / Program / Phase: 1993 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: Edward M. Davis
Award Amount: $498,070.00
Abstract:
There is a need to develop a pretreatment against the chemical warfare agents hydrogen cyanide and cyanogen chloride. the proposed work aims to use sulfurtransferases and synthetic chelating agents to combat cyanide poison.

Toxin Prophylaxis

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Edward M. Davis, Ph.d.
Award Amount: $49,942.00
Abstract:
A novel approach for developing prophylactic agents against ricin is proposed. During Phase I, a prototype of the proposed prophylactic will be synthesized and tested for its ability to detoxify ricin. The work aims to demonstrate feasibility of the proposed approach. It is anticipated that the… More

Photodetector with Multiple Analytical Capabilities

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael J. Malavasic
Award Amount: $50,000.00
Abstract:
This project outlines the development of an antibody detection system which employs a bacteriorhodopsin-based photodetection device. The photodetector is prepared by depositing purple membranes isolated from Halobacterium halobium onto an electrode. Purple membranes contain bacteriorhodopsin which… More

Permethrin-Based Topical Skin Protectant

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: HHS
Principal Investigator: Edward M. Davis
Award Amount: $74,874.00
Abstract:
Permethrin is a highly effective insecticide and tick repellent. Due to its toxicity to humans, itcan not be repeatedly applied directly on the skin. The proposed work includes preparing differentformulations of Permethrin-based tick repellent that can be applied directly to the skin. These… More

Membrane-Based Blood Reconstitution Devices

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: HHS
Principal Investigator: James Draheim
Award Amount: $74,998.00
Abstract:
We will develop microporous hollow filters (MPHF) for use in separating glycerol fromcryopreserved human blood cells following thawing. The Investigators suggest that this type systemwould be practical, efficient and economic when compared to the current centrifugation practicesemployed to… More

Distributed Coordination Infrastructure for Highly Automated Operations Support System

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: NASA
Principal Investigator: Richard M. Adler
Award Amount: $69,973.00
Abstract:
Requirements to reduce human support costs and to manage increasing complexity are driving designers to incorporate intelligent systems into ground control systems. Individual tasks such as fault diagnosis and configuration management have been automated successfully. However, less progress has been… More

NOVEL METHOD FOR RAPID ISOLATION OF WASTE BIODEGRADATIVE MICROBIAL CONSORTIA

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency / Branch: DOD / NAVY
Principal Investigator: Michael J. Malavasic, Phd
Award Amount: $67,087.00
Abstract:
A method is proposed for the rapid isolation of microbial consortia capable of biodegrading nitrate-based esters and binder/complete formulations. The isolated consortia will be usable in either in situ or ex situ bioremediation.

Chelated Transition Metal Complexes as Anticrobials

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael Malavasic
Award Amount: $100,000.00
Abstract:
There is a need to develop effective topical antimicrobial agents. The investigators will synthesizchelates and use these agents combined with or without other antibiotics to combat bacterial infectiof newborns and reduce morbidity and mortality in thermal injury patients. The synthetic chelates… More

Balanced, Membrane Mediated Hemoperfusion

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: James Draheim
Award Amount: $99,999.00
Abstract:
We will develop methods of hemopurification using sorptive techniques. Substances to be removed aremetabolites, and related compounds which will pass through membranes so that there will not be direcsorbent and blood of the patient. The approach will minimize removal of substances from blood… More

Quantitative Genome Based Method for Detecting Viruses

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Breck Parker
Award Amount: $80,327.00
Abstract:
Advances in the field of in vitro diagnostics (IVDs) have reduced the levels of hepatitis B & C inQuantitative, genome-based IVDs for-hepatitis are being developed using the polymerase chain reactioThese lVDs are more sensitive than the currently employed IVDs; therefore, they have the potential… More

Bacteriorhodopsin Optical Discriminator

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: NSF
Principal Investigator: James Draheim
Award Amount: $65,000.00

Improved Separation and Purification of Bioproducts from Cell Culture

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: NSF
Principal Investigator: Michael Malavasic
Award Amount: $65,000.00

Rapid Alignment Prototype (RAP) Flight Test Demonstration

Award Year / Program / Phase: 1996 / SBIR / Phase II
Agency / Branch: DOD / NAVY
Principal Investigator: Michael J. Malavasic, Ph. , Principal Investigator
Award Amount: $750,000.00

GLUCOSE BIOSENSOR

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $100,000.00

Compact, Diamond-Based, High-Frequency Amplifier

Award Year / Program / Phase: 1996 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $672,327.00

Development of an Innumobiosensor for Detection of PCBs

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: EPA
Principal Investigator:
Award Amount: $70,000.00

SBIR Phase I: Durable, Self-Assembled, Enzyme Biocatalysts

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: NSF
Principal Investigator: Edward Davis
Award Amount: $75,000.00

rRNA Hybridization Assay for Cryptosporidium

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: EPA
Principal Investigator: Dr. Bryan L. Ray
Award Amount: $70,000.00
Abstract:
Current methods of testing water supplies for Cryptosporidium parvum are inadequate. The lack of a reliable test led the EPA to postpone enactment of its Information Collection Rule for 2 years. The rule was recently enacted, despite any further development in testing methodologies. The… More

New Method of Deglycerolizing RBCs

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $740,022.00

Antibody Mimics for ELISA-like Detection of Toxins and DIsease Pathogens

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Robert Greenfield
Award Amount: $100,000.00
Abstract:
This Phase I Small Business Innovation Research Grant proposal will develop antibody mimics that bind to Clostridia tetanli toxin and ricin. The antibody mimics will be prepared using chemical synthetic processes without the use of animals. The antibody mimics will be evaluated for their ability… More

Three Dimensional Matrices for Culturing Cells

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency / Branch: DOD / DARPA
Principal Investigator: Robert Greenfield
Award Amount: $99,000.00
Abstract:
This Phase I Small Business Innovation Research Grant proposal will develop three-dimensional matrices for in vitro culturing of cells. Three-dimensional matrices will be developed using molecular imprinting polymer (MIP) technology. MIPs in combination with various biological extracellular matrix… More

MECHANISTIC BASED GENOTOXICITY ASSAY

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Ray, Bryan L
Award Amount: $98,216.00

NOVEL INTRACELLULAR TARGETS FOR ANTIFUNGAL AGENTS

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Greenfield, Robert S
Award Amount: $100,000.00

METHODS FOR RAPID DETECTION OF MULTIPLEX PCR PRODUCTS

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Rudolph, Daniel B
Award Amount: $100,000.00

CONTINUOUS-FLOW ELECTROPORATION CHAMBER

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Reddy, Heather L
Award Amount: $100,000.00

N/A

Award Year / Program / Phase: 1999 / SBIR / Phase II
Agency: HHS
Principal Investigator: James Draheim
Award Amount: $734,112.00

N/A

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: DOE
Principal Investigator:
Award Amount: $100,000.00
Abstract:
Not Available The melamine formaldehyde laminates are known to be most suitable for the production of hard and long-lasting working surfaces. These laminates are typically produced at high pressure using a heated press at about 150 degrees C for 20 to 30 minutes. It is suspected that, when using… More

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Wafaa M. Mahmoud
Award Amount: $100,754.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Edward M. Davis
Award Amount: $100,001.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Edward M. Davis
Award Amount: $100,001.00

AMPLIFIABLE, FLOURESCENT, AFFINITY TAGS FOR PROTEOMIC ANALYSIS

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Edward Davis
Award Amount: $100,000.00

AMPLIFIABLE, FLOURESCENT, AFFINITY TAGS FOR PROTEOMIC ANALYSIS

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Edward Davis
Award Amount: $100,000.00