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Centrifugal Cell-Retention Bioreactor

Award Information

Department of Health and Human Services
Award ID:
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Synergy Innovations, Inc.
10 Water Street Room 324 Lebanon, NH 03766
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 1993
Title: Centrifugal Cell-Retention Bioreactor
Agency: HHS
Contract: N/A
Award Amount: $50,000.00


In the production of large, complex therapeutic proteins, animal cells are preferred as the biocatalyst. Various types of production bioreactors are employed including deep-stirred and sparged tanks (with or without microcarriers), cell-immobilizing matrices, and fluidized beds of porous microcarriers. We have invented a new cell-retention technique using a centrifuge to remove and return living cells from the harvest to the bioreactor. According to the literature, this is a first-time achievement. Preliminary tests indicate high cell density, viability, cell-specific productivity relative to other animal-cell bioreactors. The objective of Phase I is to test this invention beyond the single cell line that has been tested in the laboratory to establish its feasibility as an economically important bioreactor for large-scale animal-cell culture in the production of therapeutic proteins. An extension of the work in Phase II will confirm its economic value at beta-sites in the biopharmaceutical industry and will extend its application to plant and insect cells. In Phase III, the centrifugal cell-retention bioreactor will be commercialized to become an important new bioprocessing tool.

Principal Investigator:

Robert C. Dean Jr.

Business Contact:

Small Business Information at Submission:

Synergy Research Corp.
P. O. Box 5056 Hanover, NH 03755

Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No