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DNA AND RNA HYBRIDIZATION PROBES FOR USE IN THE CLINICAL DIAGNOSIS OF INFECTIOUS DISEASE AGENTS AND FOR GENETIC SCREENING ARE UNDER INTENSIVE COMMERCIAL DEVELOPMENT.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 5323
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1986
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
10457-e Roselle Street
San Diego, CA 92121
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 RICHARD TULLIS
 PRINCIPAL INVESTIGATOR
 (619) 587-0320
Business Contact
Phone: () -
Research Institution
N/A
Abstract

DNA AND RNA HYBRIDIZATION PROBES FOR USE IN THE CLINICAL DIAGNOSIS OF INFECTIOUS DISEASE AGENTS AND FOR GENETIC SCREENING ARE UNDER INTENSIVE COMMERCIAL DEVELOPMENT. HYBRIDIZATION PROBES, EITHER CHEMICALLY SYNTHESIZED OR DERIVED FROM NATURAL OR RECOMBINANT DNA SOURCES, HAVE BEEN SHOWN TO BE HIGHLY SPECIFIC IN THE DETECTION AND IDENTIFICA-TION OF A VARIETY OF VIRUSES AND BACTERIA. SYNTHETIC OLIGO-NUCLEOTIDES HAVE ALSO BEEN SHOWN TO BE USEFUL IN DETECTING GENETIC ABNORMALITIES IN A SOUTHERN BLOT FORMAT. HOWEVER, NEARLY ALL CURRENT METHODS FOR THS USE OF HYBRIDIZATION PROBES REQUIRE EXTENSIVE SAMPLE PREPARATION FOLLOWED BY GEL-ELECTROPHORESIS OR IMMOBILIZATION ON FILTERS, HYBRIDIZATION FOR UP TO 24 HOURS, AND PROTRACTED SECONDARY PROCEDURES FOR DETECTION. THESE PROCEDURES ARE TEDIOUS, TIME CONSUMING, AND HIGHLY SPECIALIZED AND ARE NOT EASILY AUTOMATED. IN ADDITION, THE MOST SENSITIVE DETECTION TECHNIQUES RELY ON RADIOACTIVITY, WHICH PRESENTS BOTH HANDLING AND DISPOSAL PROBLEMS IN THE CLINICAL LAB. THERE IS A NEED FOR AN EFFICIENT, RAPID, EASILY AUTOMATABLE HYBRIDIZATION ANALYSIS SYSTEM WHICH CAN BE APPLIED TO RELATIVELY CRUDE SAMPLES AND IS COMPATIBLE WITH CURRENT NONISOTOPIC DETECTION METHOD- OLOGIES. THIS GRANT PROPOSES SUCH A SYSTEM.

* Information listed above is at the time of submission. *

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