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Artificial Antibody Mimetics

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65434
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
CA099126
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SYNTRIX BIOSYSTEMS, INC.
215 CLAY ST NW, STE B-5 AUBURN, WA -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2004
Title: Artificial Antibody Mimetics
Agency: HHS
Contract: 4R44CA099126-02
Award Amount: $2,176,018.00
 

Abstract:

DESCRIPTION (provided by applicant): Among the many mechanisms by which cancer arises, it is now appreciated that inappropriate phosphorylation is a key pathway. Detection agents capable of binding discrete phosphoproteins with high specificity will be important tools for research, diagnostics, and drug discovery. Currently available detection agents are most commonly antibodies or antibody mimetics made using biologic or enzymatic systems. Detection agents that rely on biology or enzymes suffer from several inherent shortcomings that include a restricted biomolecule repertoire that is time-consuming and costly to manufacture. Syntrix proposes to develop a MetaMorph technology that completely bypasses biologic and enzymatic sources with novel synthetic mimetics comprising PNA-cyclopeptide heterotetramers. MetaMorphs will be identified using a novel and purely chemical discovery paradigm termed PNA-display. We hypothesize that PNA-display will permit us to screen very large heterotetramer populations and identify at least moderate- to high-affinity mimetics in a facile system. High-affinity MetaMorphs will provide a phosphoprotein detection capability equivalent to that of antibodies and other biologically derived mimetics, but without the disadvantages. The SBIR Phase I proposal is designed to prove the feasibility of using PNA-display to identify at least moderate affinity MetaMorphs. Demonstrating feasibility will set the stage to move into an aggressive Phase II program to develop high-affinity MetaMorphs capable of detecting phosphotyrosine embedded within peptides having numerous different primary sequences. Such a MetaMorph collection will be capable of detecting hundreds of known and unknown phosphoproteins and will be of significant utility in basic science, diagnostics, and efforts to develop drugs that modulate protein kinases and phosphatases.

Principal Investigator:

John A. Zebala
2538338009
jzebala@syntrixbio.com

Business Contact:

John Zebala
2538338009
JZEBALA@EARTHLINK.NET
Small Business Information at Submission:

SYNTRIX BIOSYSTEMS, INC.
SYNTRIX BIOSYSTEMS, INC. 215 CLAY ST NW, STE B-5 AUBURN, WA 98001

EIN/Tax ID: 911981291
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No