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EXPRESSION OF MALARIA CSP ANTIGEN IN RECOMBINANT HERPESVIRUS

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
4454
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
4454
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Syntro Corp.
10655 Sorrento Valley Rd San Diego, CA 92121
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1988
Title: EXPRESSION OF MALARIA CSP ANTIGEN IN RECOMBINANT HERPESVIRUS
Agency / Branch: DOD / ARMY
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

MALARIA IS ONE OF THE MOST IMPORTANT PARASITIC DISEASES OF MAN. IT IS CAUSED BY SPECIES OF THE PROTOZOAN PLASMODIUM WHICH HAVE A COMPLEX LIFE CYCLE OF SEVERAL DEVELOPMENTAL STAGES THAT OCCUR IN BOTH MAN AND THE INSECT VECTOR ANOPHELINE MOSQUITO. RECENTLY, SEVERAL PLASMODIUM GENES HAVE BEEN CLONED THAT HAVE BEEN SHOWN TO CODE FOR ANTIGENS PRESENTED BY BOTH SPOROZOITES AND MEROZOITES. THESE ANTIGENS HAVE BEEN EXPRESSED IN BACTERIA AND SOME OF THEM WILL SOON BE UNDERGOING CLINICAL TRIALS AS CANDIDATES FOR SUBUNIT VACCINES. SYNTRO HAS DEVELOPED THE TECHNOLOGY FOR ATTENUATING HERPESVIRUSES AND FOR USING THESE VIRUS VECTORS FOR THE EXPRESSION OF FOREIGN GENES. IN THIS PHASE I APPLICATION WE PROPOSE TO EXPRESS THE CIRCUMSPOROZOITE SURFACE ANTIGEN (CSP) OF P.FALCIPARUM IN RECOMBINANT PSEUDORABIES OF SWINE. THE ENGINEERED VIRUS WILL BE INOCULATED INTO WEANLING PIGS AND THE PRODUCTION OF ANTI-CSP ANTIBODY WILL BE ASSAYED. POSITIVE RESULTS WILL INDICATE THAT THIS APPROACH IS FEASIBLE FOR THE DEVELOPMENT OF A MALARIA VACCINE FOR HUMANS AND WILL LEAD TO A PHASE II APPLICATION TO DEVELOP A HUMAN VACCINE USING A RECOMBINANT HERPERSVIRUS AS A VECTOR.

Principal Investigator:

Dr Richard D Macdonald
6194534000

Business Contact:

Small Business Information at Submission:

Syntro Corp.
10655 Sorrento Valley Rd San Diego, CA 92121

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No