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Nitroxide Labeled Hemoglobin as a Blood Substitute

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29514
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
29514
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SYNZYME TECHNOLOGY, INC.
1 TECHNOLOGY DR, B-115 IRVINE, CA 92618-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1995
Title: Nitroxide Labeled Hemoglobin as a Blood Substitute
Agency: HHS
Contract: 1 R43 HL53860-01,
Award Amount: $98,400.00
 

Abstract:

A number of biopharmaceutical companies have successfully taken hemoglobin-based oxygen carriers (Hinto phase I clinical trial. However, transfusions have been limited to low dosage levels due to obsvasoconstrictive effects at high dosage levels in pre-clinical animal studies. This proposal deals wfailure to have an oxidant detoxification system similar to the one which is intrinsic to the red blsubstitute. This research plan intends to modify a high- quality HBOC, which is currently in clinicathat stable nitroxide free radicals can be used to perform an oxidant detoxification function. If ththen the groundwork would established for a second generation red blood cell substitute which couldcommercialized.

Principal Investigator:

Carleton Hsia
71453

Business Contact:

Small Business Information at Submission:

Synzyme Technology, Inc.
1 Technology Drive, E-309 Irvine, CA 92718

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No