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Multi-Analyte Biosensor Using Laser Diode Based Lifetime Fluorometer

Award Information

Department of Defense
Air Force
Award ID:
Program Year/Program:
1998 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Systems & Processes Engineering Corporat
7050 Burleson Road Austin, TX 78744
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 2
Fiscal Year: 1998
Title: Multi-Analyte Biosensor Using Laser Diode Based Lifetime Fluorometer
Agency / Branch: DOD / USAF
Contract: N/A
Award Amount: $749,930.00


Systems & Processes Engineering Corp. (SPEC) proposes to develop a compact, low-cost multi-analyte immunomagnetic biosensor system for rapid, selective, and sensitive detection and identification of several individual viruses and toxins simultaneously in a biotoxoid mixture. The proposed biosensing system will incorporate the following SPEC developed technologies: (1) Low-Cost Phase Resolved Fluorescence Spectroscopy (PRFS) Technology; (2) Lifetime Chemometric Extraction Algorithms; (3) Phage Epitope and DNA Probe Technology; and (4) Low-Cost Near-Infrared (NIR) Fluorescent Dye Technology. Implementation of these SPEC technologies will provide improved portability, sensitivity and detection capabilities over current immunomagnetic sensor systems. Working with Dr. J. P. Chambers of the University of Texas at San Antonio (UTSA), SPEC will ligate near-infrared dyes to novel biological recognition molecules. SPEC will work with AF and DoD sponsors to determine the biological recognition molecules of interest. The Phase I program will result in a NIR-PRFS Multi-Analyte Immunomagnetic Biosensor design and laboratory demonstration. Additionally, novel biological recognition molecules will be developed and ligated with NIR dyes. In Phase II, a prototype of this Biosensor system will be developed, tested and delivered to the AF for field evaluation.

Principal Investigator:

Dr. Robert Chin

Business Contact:

Small Business Information at Submission:

Systems & Processes
401 Camp Craft Road Austin, TX 78746

Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No