Monoclonal antibodies specific for a human lung tumor-associated glycoprotein antigen (gp-160) will be used to develop and test a cytotoxic prognostic immunoassays. the gp-160 is a membrane-associated glycoprotein that is found in significant levels on several major types of human lung tumors… More

A new concept for the separation of cells will be developed and evaluated. the basis of this separation technique, called immunoflotation, is a solid matrix that floats in water, making it possible to separate bound cells from unbound cells without centrifugation. either antigen or antibody is… More

A novel approach to the generation of human monoclonal antibodies will be investigated. c.b-17 scid/scid (scid) mice will be engrafted with human peripheral blood lymphocytes (pbl). these animals will be immunized with a variety of antigens to provoke an immune response by the human pbl. antigens to… More

DESCRIPTION: A novel technology for the local and sustained delivery of immunostimulatory molecules to the tumor environment for cancer immunotherapy is evaluated. The ability of biodegradable polymer micro spheres loaded with murine Interleukin- 12 to promote the… More

The cytokine Interleukin-10 (IL-10) has shown promise in clinical trials for the treatment of inflammatory bowel disease (IBD). Currently IL-10 is administered to IBD patients systemically either by bolus intravenous or subcutaneous injections. Due to the short in vivo half-life of IL-10, repeated… More