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Broad Cross-Reactivity of HIV-1 Neutralizing Antibody

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
24767
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
24767
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
TANOX, INC.
10301 STELLA LINK RD HOUSTON, TX 77025
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1994
Title: Broad Cross-Reactivity of HIV-1 Neutralizing Antibody
Agency: HHS
Contract: 1 R43 AI35427-1,
Award Amount: $75,000.00
 

Abstract:

Passive immunization with broadly neutralizing antibodies is a promising approach for preventionand treatment of HIV-1 infection. We have generated an HIV-1 neutralizing human antibody which bindsto the principal neutralizing determinant (PND) of the envelope glycoprotein gp12O. The antibody showsstrong binding to diverse laboratory isolates as well as good neutralization ability for some of theseisolates. Like other Mabs of this class, our antibody is limited in binding to a few HIV-l subtypes. Wewill study to broaden the reactivity of the antibody through a novel combination of molecular modellingand use of the antibody phage display system. In a Phase II study, promising clones with increasedreactivity will be analyzed in more detail for biological activity. This analysis will also lead to furtherrefinement of our approach.

Principal Investigator:

Joseph Major
7136642288

Business Contact:

Small Business Information at Submission:

Tanox Biosystems, Inc.
10301 Stella Link Road Houston, TX 77025

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No