DESCRIPTION (provided by applicant): We propose to develop a novel acoustically activated microbubble gene delivery vehicle for treatment of experimental inflammatory bowel disease. Microbubble ultrasound contrast agents composed of a cationic lipid shell are targeted to the adhesion molecule… More

DESCRIPTION (provided by applicant): Targeson has developed and commercialized a microbubble contrast agent that is suitable for conjugation to an array of molecular targeting ligands via an avidin/biotin coupling system. The potential immunogenicity and t oxicity of the avidin/biotin system, as… More

DESCRIPTION (provided by applicant): We propose to develop molecular imaging probes for imaging angiogenesis and inflammation using contrast-enhanced ultrasound. These probes are gas-encapsulated microbubbles that can be coated with ligands specific for mo lecular markers of disease using robust… More

DESCRIPTION (provided by applicant): Antibodies can be used diagnostically as ligands for molecular imaging, and also as therapeutic to neutralize factors involved in the development of kidney disease. However, the systemic administration of many relevant antibodies may lead to serious side-effects… More

DESCRIPTION (provided by applicant): Site-targeted microbubbles (MB) have demonstrated potential as a molecular imaging tool. A new targeted MB platform was developed in phase I of this project. This MB enables covalent coupling of targeting ligands using thioether conjugation chemistry. MB bearing… More

DESCRIPTION (provided by applicant): Molecular imaging techniques have demonstrated efficacy in the setting of preclinical research, primarily for drug discovery and basic science. Optical imaging has emerged as a market leader in the field, owing to the a vailability of easy-to-use contrast agents… More

DESCRIPTION (provided by applicant): Molecular imaging techniques have strong potential in the setting of preclinical research, primarily for drug discovery and basic science in the field of cancer research. In particular, high-frequency ultrasound is a powerful imaging modality for phenotyping and… More