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PRODUCTION OF RECOMBINANT HTLV-II ENVELOPE PROTEIN IN E. COLI

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13744
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
13744
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Tbc Research Laboratories
950 Boston Ave Longmont, CO 80501
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: PRODUCTION OF RECOMBINANT HTLV-II ENVELOPE PROTEIN IN E. COLI
Agency: HHS
Contract: N/A
Award Amount: $45,000.00
 

Abstract:

HUMAN T-CELL LEUKEMIA VIRUS TYPE II (HTLV-II) IS CONSIDERED TO BE AN ETIOLOGIC AGENT OF HAIRY CELL LEUKEMIA, AND ITS PREVALENCE IS INCREASING IN THE BLOOD SUPPLY. THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO PRODUCE AN IMMUNOLOGICAL ASSAY TO STUDY ITS PREVALENCE IN THE BLOOD SUPPLY. THIS PHASE I RESEARCH SPECIFICALLY AIMS TO DEVELOP A RECOMBINANT DNA SYSTEM TO PRODUCE A PORTION OF THE ENVELOPE PROTEIN THAT IS IMMUNOGENIC. THE APPROACH TO BE USED WILL INVOLVE THE ASSEMBLY OF A SYNTHETIC GENE CODING FOR THAT PORTION OF THE ENVELOPE PROTEIN. THE GENE WILL BE CLONED AND EXPRESSED IN E. COLI. HIGH-LEVEL EXPRESSION OF THE DESIRED PRODUCT WILL ENABLE PHASE II RESEARCH TO FOCUS ON THE E. COLI FERMENTATION SCALE-UP AND PURIFICATION.

Principal Investigator:

Yitzhak Stabinsky
3036516419

Business Contact:

Small Business Information at Submission:

Tbc Research Laboratories
950 Boston Ave Longmont, CO 80501

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No