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AN IN VITRO TOXICITY TESTING DATABANK

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13764
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
13764
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Technical Database Services In
10 Columbus Cir #2300 New York, NY 10019
View profile »
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: AN IN VITRO TOXICITY TESTING DATABANK
Agency: HHS
Contract: N/A
Award Amount: $46,269.00
 

Abstract:

ADVANCES IN BIOTECHNOLOGY HAVE LED TO THE DEVELOPMENT OF NEWIN VITRO TOXICITY TESTING METHODOLOGIES THAT ARE APPLICABLE TO THE EVALUATION OF CHEMICAL SAFETY. IMPETUS FOR THE DEVELOPMENT OF IN VITRO TESTS DERIVES FROM THE NEED FOR RAPID, INEXPENSIVE, AND MORE HUMANE APPROACHES THAT MAY SERVE AS ALTERNATIVES TO TESTS INVOLVING WHOLE ANIMALS. HOWEVER, THE IMPLEMENTATION OF IN VITRO METHODOLOGIES HAS BEEN SLOWED BECAUSE VALIDATION FOR SPECIFIC APPLICATIONS HASNOT BEEN ESTABLISHED. THIS RESEARCH AIMS TO DEVELOP THE IN VITRO TOXICITY TESTING DATABANK (IVT), WHICH WILL INTEGRATE AN INVENTORY OF TEST PROCEDURES AND EXPERIMENTAL DATA FOR VALIDATION PURPOSES. THE OBJECTIVES ARE TO: (1) COMPILE A COMPLETE INVENTORY OF IN VITRO METHODOLOGIES, (2) MAINTAIN AND UPDATE AN EXPERIMENTAL DATA COLLECTION REQUIRED FOR VALIDATING NEW TESTS, (3) DEVELOP AN AUTOMATED INSTRUMENT FOR COMMUNICATINGWITH SCIENTISTS WHO ARE DEVELOPING AND APPLYING NEW METHODOLOGIES, AND (4) MAINTAIN A COMPUTERIZED SYSTEM THROUGH WHICH INDUSTRY, GOVERNMENT AGENCIES, AND ACADEMIA CAN ACCESS INFORMATION REQUIRED FOR THE VALIDATION AND SELECTION OF AVAILABLE TESTS. IN PHASE I, A PROTOTYPE DATABASE OF IN VITRO TESTS FOR CYTOTOXICITY AND OCULAR IRRITATION WILL BE DEVELOPED. IN PHASE II, THE DATABANK WILL BE EXPANDED TO INCLUDE NEW TEST CATEGORIES AND SOFTWARE THAT WILL MAKE IVT SUITABLE FOR ONLINE ACCESS.

Principal Investigator:

Mildred R Green
2122450044

Business Contact:

Small Business Information at Submission:

Technical Database Services In
10 Columbus Cir #2300 New York, NY 10019

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No