USA flag logo/image

An Official Website of the United States Government

ULTRASOUND ASSISTED ASSAY FOR TOXINS IN BLOOD

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
13056
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
13056
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
TECHNICAL RESEARCH ASSOC., INC.
P.O. Box 15278 Honolulu, HI 96830
View profile »
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: ULTRASOUND ASSISTED ASSAY FOR TOXINS IN BLOOD
Agency / Branch: DOD / ARMY
Contract: N/A
Award Amount: $55,000.00
 

Abstract:

THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO SUCCESSFULLY COMBINE ULTRASOUND TECHNOLOGY DEVELOPED AT TRA WITH ASSAY METHODS AND PECTROSCOPIC ANALYTICAL TECHNIQUES FOR DETECTING SPECIFIC TOXINS IN WHOLE BLOOD SAMPLES. THE RESEARCH IN PHASE I OF THIS PROPOSAL FOCUSES ON THE APPLICATION OF THIS METHODOLOGY TO THE ANALYSIS OF SAXITOXIN. THE KNOWN CHEMICAL ASSAY METHOD WILL BE MODIFIED FOR COATING IN HEMATOCRIT TUBES, AND THE COMPOSITION OF THE FORMULATION WILL BE OPTIMIZED FOR RAPID FLUORESCENT DETECTION OF SAXITOXIN DEGRADATION PRODUCT IN PLASMA. TUBES COATED WITH THE OPTIMUM FORMULATION WILL THEN BE USED TO SAMPLE WHOLE BLOOD WHICH WILL SOLUBILIZE THE ASSAY FORMULATION. ULTRASOUND WILL BE USED TO BAND WHOLE BLOOD INTO PACKED CELL AND PLASMA REGIONS, AND THE SAXITOXIN LEVELS WILL BE DETERMINED BY FLUORESCENT ANALYSIS OF THE PLASMA REGIONS. SUCCESSFUL COMPLETION OF THE PHASE I RESEARCH WILL DEMONSTRATE A STRAIGHTFORWARD METHOD FOR BLOOD ANALYSIS THAT CAN BE ADAPTED FOR DETECTION OF A WIDE VARIETY OF TOXINS (PHASE II). THIS METHODOLOGY WOULD THEN BE SUITABLE FOR FIELD USE INASMUCH AS IT REQUIRES SMALL AMOUNTS OF BLOOD, INEXPENSIVE AND DISPOSAL EQUIPMENT, AND MINIMALLY TRAINED PERSONNEL.

Principal Investigator:

Dr Clifton G Sanders
8015828080

Business Contact:

Small Business Information at Submission:

Technical Research Assocs Inc
410 Chipeta Wy Salt Lake City, UT 84108

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No