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ULTRASOUND-ENHANCED INVERTED BONE MARROW FRACTIONATION

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13968
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
13968
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
TECHNICAL RESEARCH ASSOC., INC.
P.O. Box 15278 Honolulu, HI 96830
View profile »
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1992
Title: ULTRASOUND-ENHANCED INVERTED BONE MARROW FRACTIONATION
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

THE OVERALL OBJECTIVE OF THIS PROJECT IS TO DESIGN, DEVELOP, AND CONSTRUCT A BONE MARROW SEPARATION DEVICE THAT WILL OFFER SIGNIFICANTLY SUPERIOR PERFORMANCE COMPARED WITH CURRENT METHODS OF VELOCITY SEDIMENTATION. IN PHASE I, TECHNICAL RESEARCH ASSOCIATES, INC. (TRA) WILL APPLY PATENTED PSEUDOSTANDING WAVE ULTRASOUND TECHNOLOGIES TO SEPARATE BONE MARROW CELLS BY SIZE. THIS NOVEL DEVICE WILL ELIMINATE THE TRADITIONAL CELL CONCENTRATION PROBLEM REFERRED TO AS THE "STREAMING LIMIT" ASSOCIATED WITH VELOCITY SEDIMENTATION, USING AN ACOUSTICALLY INVERTED SEPARATION COLUMN. USING SAFE LEVELS OF ULTRASOUND, THE FORCES GENERATED BY TRA'S ULTRASONIC MEANS ARE SIGNIFICANTLY HIGHER THAN TRADITIONAL "G" FORCES AND WILL EFFECT RAPID CELL SEPARATION. THE USE OF ULTRASONICALLY GENERATED VELOCITY GRADIENTS WILL ALSO ELIMINATE THE NEED FOR THE TEDIOUS AND DIFFICULT FORMATION OF DENSITY GRADIENTS ASSOCIATED WITH STANDARD VELOCITY SEDIMENTATIONS. THIS TECHNIQUE, WHEN INTEGRATED INTO COMMERCIAL SEPARATION SYSTEMS, WILL PROVIDE MORE EFFICIENT COLLECTION OF SPECIFIC BONE MARROW AND OTHER BIOLOGICAL CELLS FOR CLINICAL TREATMENT. THE DEVICE WILL ALSO SAVE TIME, DECREASE COSTS, AND PROVIDE UNIQUE PERFORMANCE FOR THOSE INTERESTED IN FRACTIONATION OF BULK QUANTITIES OF CELLS OR BONE MARROW COMPONENTS.

Principal Investigator:

Owen D Brimhall
8015828080

Business Contact:

Small Business Information at Submission:

Technical Research Assoc Inc.
410 Chipeta Way #222 Salt Lake City, UT 84108

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No