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DEVELOPMENT OF A HIGHLY COMPLIANT VASCULAR GRAFT

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3257
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
3257
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Thoratec Laboratories Corp
2023 8th St Berkeley, CA 94710
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1987
Title: DEVELOPMENT OF A HIGHLY COMPLIANT VASCULAR GRAFT
Agency: HHS
Contract: N/A
Award Amount: $263,000.00
 

Abstract:

A NEW, HIGHLY COMPLIANT VASCULAR GRAFT FABRICATED FROM A UNIQUE POLYURETHANE MATERIAL WILL BE DEVELOPED AND TESTED. THE BULK AND SURFACE PROPERTIES REQUIRED OF THIS MATERIAL HAVE BEEN DECOUPLED AND DEVELOPED INDEPENDENTLY IN TWO SEPARATE MATERIALS. THE FINAL POLYMER WILL POSSESS OVERALL OPTIMIZED CHARACTERISTICS BY BLENDING OPTIMIZED SURFACE ACTIVE COPOLYMERS INTO THE OPTIMIZED BULK MATERIAL. USING A PATENTED PROCESS FOR FABRICATION OF MULTILAYERED TUBING, 4 MM DIAMETER VASCULAR GRAFTS WILL BE PRODUCED. THESE GRAFTS WILL BE TESTED BOTH IN VIVO AND IN VITRO. IN VITRO TESTING WILL INCLUDE COMPLIANCE, BURST STRENGTH, KINK RADIUS, ELONGATION, AND SUTURE PULLOUT STRENGTH. IN VIVO EVALUATION WILL BE ACCOMPLISHED BY IMPLANTING 8 CM LENGTHS IN THE CAROTID ARTERIES OF MATURE GOATS. THESE WILL BE CHECKED FOR PATENCY EVERY 30 DAYS USING 99MTECHNETIUM SCANNING. AFTER 60 DAYS OF OBSERVATION, GRAFTS WILL BE EXPLANTED AND RESUBJECTED TO THE IN VITRO TEST PROTOCOL. ADDITIONALLY, BOTH SEM AND STANDARD MICROSCOPIC EXAMINATIONS WILL BE PERFORMED.

Principal Investigator:

Philip Litwak
Principal Investigator
4158411213

Business Contact:

Small Business Information at Submission:

Thec Laboratorytories Corp.o
2023 Eighth St. Berkeley, CA 94710

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No