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ADJUVANT ACTIVITY OF BUTYROLACTONE DRUGS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
11409
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
11409
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Theracel Corpon
7658 Standish Pl Ste 107 Rockville, MD 20855
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1989
Title: ADJUVANT ACTIVITY OF BUTYROLACTONE DRUGS
Agency: HHS
Contract: N/A
Award Amount: $49,771.00
 

Abstract:

BUTYROLACTONES ARE NOVEL, NONTOXIC, WATER-SOLUBLE, LOW-MOLECULAR-WEIGHT COMPOSITIONS DEVELOPED BY THE THERACEL CORPORATION. THE KETOBUTYROLACTONES, WHICH ARE IMMUNOSTIMULATORY, WERE ASSESSED FOR THEIR UTILITY AS VACCINE ADJUVANTS. THE EXPERIMENTAL DESIGN EMPLOYED IMMUNIZATION WITH COMMERCIALLY PREPARED VACCINES TO TETANUS AND INFLUENZA, AND A SYNTHETIC PEPTIDE OF HIV-1, GP-41. THEVACCINES WERE ADMINISTERED IN EITHER SOLUBLE OR ALUM-ADSORBED FORMS, AND THE EFFECT OF TREATMENT WITH THE BUTYROLACTONES ON HUMORAL AND CELL-MEDIATED IMMUNE RESPONSESWAS ASSESSED. BECAUSE BUTYROLACTONES ARE ACTIVE ORALLY, THE CONCEPT OF AN ORAL ADJUVANT FOLLOWING VACCINATION WAS EVALUATED. A KETOBUTYROLACTONE (BL-009) WAS SELECTED AS A POTENTIAL ADJUVANT BASED ON ITS ABILITY TO STIMULATE BOTH HUMORAL AND CELL-MEDIATED IMMUNITY (CMI). BL-009, WHEN ADMINISTERED ORALLY, STIMULATED ANTIBODY FORMATION IN ANIMALS RECEIVING ALUM-ADSORBED TETANUS TOXOID AND INFLUENZA HEMAGGLUTININ. ORALLY ADMINISTERED BL-009 SHOWED A SIGNIFICANT ENHANCEMENT OF CMI RESPONSES OF MICE TO THE INTRAMUSCULARLY INJECTED, SOLUBLE HIV-1 PEPTIDE. THE HUMORAL RESPONSE TO THE PEPTIDE IN BOTH THE SOLUBLE AND ALUM-ADSORBED FORMS WAS ALSO ENHANCED. THESE RESULTS SUPPORT THE NEED FOR CONTINUED RESEARCH ON THE IMMUNOSTIMULATORY ACTIVITY OF BUTYROLACTONES IN COMBINATION WITH NEW VACCINES WITH EMPHASIS ON THOSE VACCINES UNDER DEVELOPMENT FOR THE PREVENTION OF AIDS.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Theracel Corpon
7658 Standish Pl Ste 107 Rockville, MD 20855

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No