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EPITHERMAL NEUTRON-BEAM APPROACH TO NEUTRON CAPTURE THERAPY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7175
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7175
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Theragenics Corp
900 Altantic Dr Northwest Atlanta, GA 30318
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: EPITHERMAL NEUTRON-BEAM APPROACH TO NEUTRON CAPTURE THERAPY
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THERAGENICS CORPORATION HAS DEVELOPED THE FIRST FILTER DEVICE TO GENERATE A DEEPLY PENETRATING, HIGH-FLUX, EPITHERMAL NEUTRON BEAM FREE OF SIGNIFICANT FAST NEUTRON CONTAMINATION. THE DEVICE IS A PROTOTYPE OF A THERAPEUTIC VERSION INTENDED FOR USE IN AN ALTERNATIVE FORM OF RADIATION THERAPY KNOWN AS BORON NEUTRON CAPTURE THERAPY (BNCT). THE EPITHERMAL NEUTRON BEAM WILL ULTIMATELY BE COUPLED WITH A THERAGENICS CORPORATION ORPHAN DRUG, NA2 (10)B12H11SH, FORTHE TREATMENT OF THE EXTREMELY MALIGNANT BRAIN TUMOR, GLIOBLASTOMA MULTIFORME. UPON FOOD AND DRUG ADMINISTRATION (FDA) APPROVAL OF BOTH THE DRUG AND DEVICE, RADIATION SERVICES WILL BE OFFERED THAT ARE MUCH LIKE THOSE IN RADIATION THERAPY AND ONCOLOGY DEPARTMENTS IN MAJOR HOSPITALS. PHASE I CONSISTS OF REBUILDING AND OPTIMIZING THE PROTOTYPE DEVICE FOR THERAPEUTIC PURPOSES. PHASE II INVOLVES EXTENSIVE CHARACTERIZATION OF THE RESULTANT EPITHERMAL NEUTRON BEAM, FULFILLING FDA REQUIREMENTS FOR AN INVESTIGATIONAL DEVICE EXEMPTION (IDE) APPLICATION. PHASE II WILL THEN CONTINUE WITH TWO ANIMAL STUDIES TO ASSESS THE SAFETY OF THE GLIOBLASTOMA TREATMENT. THE RESULTS OF THESE STUDIES WILL FINALIZE PROTOCOLS FOR CLINICAL TRIALS OF EPITHERMAL NEUTRON BEAM BNCT.

Principal Investigator:

John l russell jr phd
4048736309

Business Contact:

Small Business Information at Submission:

Theragenics Corp
900 Altantic Dr Northwest Atlanta, GA 30318

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No