We will develop a novel system for directed nucleic acid cleavage. This system is based uponour discovery that the 5' nucleases of several thermostable DNA polymerases can be directed to cleaveas site-specific endonucleases. This system will be thermostable, specific, efficient and… More

We will commercialize a high-speed instrument for automated DNA sequence analysis. Such an instrument is essential to the success of the Human Genome Initiative; the sequence of the human genome will be determined and used as a powerful tool for biological and medical research. Two key aspects of… More

This project will attempt to commercialize a novel, high-speed, and automatable dna and rna diagnostic technology for the specific detection of nucleic acid sequence changes associated with genetic diseases. this technology is based on the discovery that the 5' nuclease of several thermostable dna… More

Not Available Effective use of large area SIC thyristors has been limited by the decreasing breakdown strength as the size of device increases. The proposed project aims to develop a cost-effective method to greatly improve the breakdown voltage of devices and minimize the dependence of their… More

Not Available Dynetics, Incorporated proposes to design (Phase I) and develop (Phase I and Phase II) an infrastructure within which the Air Force Research Lab Munitions Directorate can integrate software modules for vulnerability and lethality assessment. The objective of this effort is to address… More

The goal of this project over Phase I is to create and test the analytical validity of novel Invader mutation detection assays designed for applications specific to surgery and anesthesia. Invader technology, based on a highly specific enzyme-substrate reaction, enables direct analysis of genomic… More

The goal of this project is to create a high throughput, sensitive, quantitative and cost-effective platform for measuring gene expression in response to natural compounds derived from foods -nutraceuticals. This technology, the RNA InvaderTM assay, offers highly sensitive detection of mRNA… More

DESCRIPTION (provided by applicant): The objectives of Phase II are to develop, validate, and commercialize a tool for detecting genotypes affecting patient care and safety during the perioperative interval (before, during, and immediately following surgery). Despite publications describing genetic… More

DESCRIPTION (provided by applicant): The objectives of Phase II are to develop, validate, and commercialize a tool for detecting genotypes affecting patient care and safety during the perioperative interval (before, during, and immediately following surgery). Despite publications describing genetic… More