DESCRIPTION (provided by applicant): Based on the extensive data generated
during the phase I portion of our studies, there is sufficient and compelling
information to support the further development of the highly lipophilic and
blood-stable topoisomerase inhibitor, DB-67.… More
DESCRIPTION (PROVIDED BY APPLICANT): DB-67 is a promising new silatecan
(silylcamptothecin) analog that displays superior blood stability relative to
the FDA-approved camptothecin congeners, topotecan and CPT- 11. DB-67 also
exhibits a high degree of anti-cancer potency… More