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Thin Film Sensor for Specific DNA Sequences

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29116
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
29116
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Transducer Research Inc.
6800 Cortona Drive Goleta, CA 93117
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1995
Title: Thin Film Sensor for Specific DNA Sequences
Agency: HHS
Contract: 1 R43 AI38090-01,
Award Amount: $97,754.00
 

Abstract:

A chemical sensor has been discovered which can be made to sensitively detect enzyme activity and aantibody reactions. It consists of an ultrathin (25 Angstroms) layer of platinum on an insulating sumeasure dielectric constant and other properties within molecular-scale distances of the surface. Wesensor be adapted to measure nucleic acid hybridization. Short, 20-nucleotide probes will be bound ttheir 3'-ends. Complementary strands will be hybridized with the probes, and the effect on the impedsensor will be observed. The double-stranded form will differ greatly in shape, electrostatic chargeall of which should affect the response of the thin-film sensor. Such a sensor may be useful as a rediagnostic tool for early HIV infection, genetic diseases, pathogen identification, and forensic pur

Principal Investigator:

William Penrose
70869

Business Contact:

Small Business Information at Submission:

Transducer Research, Inc.
999 Chicago Avenue Naperville, IL 60540

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No