Integrated flow cytometer for on-line, real-time unlabeled bio detection in potable water
Agency / Branch:
DOD / ARMY
Quantifying and classifying biological particles (bacteria, viruses, and cells) in drinking water and on beaches is critical to human health and environmental safety. The optimal solution is an on-line, real-time detection system continuously monitoring water without calibration or other attention. This technology has been elusive. Lab-on-a-chip ("LOC") PCR DNA detectors are viable contenders, but are a long way off. Flow cytometry uses optical techniques to detect and classify cells as they flow past in an on-line stream and integrates the cumulative signal to the desired detection level without pre-concentrators (another technology that is some time off). Translume's ability to write optical waveguides and complex microfluidic channels in a glass monolith enables a compact and robust micro flow cytometer (MFC), reducing this complex and delicate instrument into a simple single-piece unit. The MFC will address sample preparation, pre-concentration, and process time, all significant difficulties facing on-line water monitoring systems. Translume proposes to design and prototype an MFC in a single block of glass to determine the viability of this approach to yield a robust and field-deployable device for on-line water monitoring.
Small Business Information at Submission:
655 Phoenix Drive Ann Arbor, MI 48108
Number of Employees: