Based on preliminary results, construction of a general system for detection of DNA at thepicogram (1 x 10(-12)) level may be possible. The system would work in most aqueous solutionswithout regard to the sequence of the DNA. As proposed, it does not require sophisticatedinstrumentation and should… More

The function of retroviral integrase (IN) is the integration of viral DNA into host cell DNA, an esretroviral replication. IN protein recognizes viral cognate at sites, removes two nucleotides from tviral DNA (3' processing) and joins the 3'-processed cognate at sites to the newly created 5' ends… More

TreviMed has developed a novel patent pending technology, Oscillating Cleavage Amplification Reaction (OsCAR), for the detection of point mutations in clinical samples. The entire assay will take about one hour from preparation of the DNA sample and will utilize capillary electrophoretic… More

Not Available Reconfigurable multivariable flight control using an indirect adaptive algorithm is proposed for aeroservoelastic (ASE) instability and flutter suppression in the presence of aircraft system failure or battle damage. A reduced order procedure using an effective and rigorous proper… More

DESCRIPTION (provided by applicant): The comet assay allows for the detection of DNA damage in any accessible cell population and a molecular definition of the DNA damage is possible with adaptation of the basic assay. Trevigen has developed a platform for the comet assay consisting of a specially… More

DESCRIPTION (provided by applicant): Trevigen/TreviMed has developed the Mutation Identification DNA Analysis System (MIDAS TM) that relies on DNA mismatch repair enzymes (MREs) for the detection and identification of known point mutations and pathogen DNA without the need for PCR amplification. The… More

DESCRIPTION (provided by applicant): Trevigen/TreviMed has developed the Mutation Identification DNA Analysis System (MIDAS TM) that relies on DNA mismatch repair enzymes (MREs) for the detection and identification of known point mutations and pathogen DNA without the need for PCR amplification. The… More

DESCRIPTION (provided by applicant): Trevigen/TreviMed has developed the Mismatch Identification DNA Analysis System (MIDAS) that relies on SNIPase (genetically-optimized DNA mismatch repair enzymes) for the detection of pathogen DNA without the need for PCR amplification. The purpose of the… More

DESCRIPTION (provided by applicant): The Centers for Disease Control and Prevention (CDC) estimate that, in the United States, there are in excess of 75 million illnesses per year, 300,000 hospitalizations, and 5,000 deaths annually that are directly attr ibuted to food-borne pathogens [1]. E. coli… More

DESCRIPTION (provided by applicant): The single cell gel electrophoresis (SCGE) or comet assay is now recognized worldwide as a simple and inexpensive method for detection of different types of DNA damage. Adoption of the comet assay for genotoxic studies has been hampered to date by the lack of a… More

DESCRIPTION (provided by applicant): Human Papilloma Virus (HPV) comprises a family of viruses of over 100 different strains. The high-risk strains of HPV cause cervical cancer, which is the second leading cause of female cancer mortality worldwide with 288,000 deaths yearly. The goal of the… More

DESCRIPTION (provided by applicant): The single cell gel electrophoresis (SCGE) or Comet assay, is now internationally recognized as a simple and inexpensive method for the detection of different types of DNA damage, including single- and double- strande d breaks, DNA adducts, cross-links, and… More

DESCRIPTION (provided by applicant): Human illness results from the complex interactions of integrated processes and factors, including genetic predispositions and environmental agents. The environmental genome project (EGP) was formally initiated to syste matically and comprehensively evaluate how… More

DESCRIPTION (provided by applicant): Successful completion of Phase I led to the development a panel of human cell lines, each deficient in one of the eleven DNA glycosylase enzymes. Depletion of target mRNA was as high as 95%, with corresponding depletion of target protein levels and enzymatic… More

DESCRIPTION (provided by applicant): Human exposure to dangerous genotoxins is unavoidable, as DNA damaging agents are ubiquitous both in our environment and within our cells. DNA damaging agents and other genotoxins that arise from cellular metabolism, environmental sources or disease-related… More

DESCRIPTION (provided by applicant): Apoptosis is an evolutionarily conserved cell death process that involves over 100 gene products. In response to cellular stress or to maintain tissue homeostasis, the apoptotic machinery initiates and carries out a series of biochemical events leading to cell… More