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Company Information:

Name: TREVIGEN, INC.
Address: 8405 HELGERMAN COURT
GAITHERSBURG, MD 20877-
Located in HUBZone: No
Woman-Owned: No
Minority-Owned: No
URL: N/A
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $2,180,145.00 17
SBIR Phase II $6,543,639.00 5

Award List:

Picogram Non-Specific DNA Detection System

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gordon Collier
Award Amount: $79,125.00
Abstract:
Based on preliminary results, construction of a general system for detection of DNA at thepicogram (1 x 10(-12)) level may be possible. The system would work in most aqueous solutionswithout regard to the sequence of the DNA. As proposed, it does not require sophisticatedinstrumentation and should… More

Development of a Fluorometric In Vitro Assay for HIV

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Philip Vanek
Award Amount: $98,224.00
Abstract:
The function of retroviral integrase (IN) is the integration of viral DNA into host cell DNA, an esretroviral replication. IN protein recognizes viral cognate at sites, removes two nucleotides from tviral DNA (3' processing) and joins the 3'-processed cognate at sites to the newly created 5' ends… More

BASE/PAIR MISMATCH ANALYSIS BY CAPILLARY ELECTROPHORESIS

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $93,513.00

Use of Superconducting Magnetic Energy Storage (SMES) to Improve...

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: NSF
Principal Investigator: Bruce Collier , Principal Investigator
Award Amount: $75,000.00

RAPID CANCER PREDISPOSITION SCREEN FOR GENE MUTATIONS

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: HHS
Principal Investigator: Bazar, leonard s
Award Amount: $100,000.00
Abstract:
TreviMed has developed a novel patent pending technology, Oscillating Cleavage Amplification Reaction (OsCAR), for the detection of point mutations in clinical samples. The entire assay will take about one hour from preparation of the DNA sample and will utilize capillary electrophoretic… More

SCREENING SYSTEM FOR ANTIAPOPTOSIS THERAPEUTICS

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: HHS
Principal Investigator: Wood, katherine a
Award Amount: $100,000.00

DEVELOPMENT OF AN ASSAY FOR DNA DAMAGE IN SITU

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vanek, Philip G
Award Amount: $100,000.00

DIAGNOSING MUTATIONS W/ THERMOPHILIC DNA REPAIR ENZYMES

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jay George
Award Amount: $100,000.00
Abstract:
Not Available Reconfigurable multivariable flight control using an indirect adaptive algorithm is proposed for aeroservoelastic (ASE) instability and flutter suppression in the presence of aircraft system failure or battle damage. A reduced order procedure using an effective and rigorous proper… More

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Katherine A. Wood
Award Amount: $99,526.00

Higher throughput comet assay for genotoxicity studies

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Janos Luka
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): The comet assay allows for the detection of DNA damage in any accessible cell population and a molecular definition of the DNA damage is possible with adaptation of the basic assay. Trevigen has developed a platform for the comet assay consisting of a specially… More

Diagnosing DNA Mutations Using Mismatch Repair Enzymes

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Leonard S. Bazar
Award Amount: $0.00
Abstract:
DESCRIPTION (provided by applicant): Trevigen/TreviMed has developed the Mutation Identification DNA Analysis System (MIDAS TM) that relies on DNA mismatch repair enzymes (MREs) for the detection and identification of known point mutations and pathogen DNA without the need for PCR amplification. The… More

Diagnosing DNA Mutations Using Mismatch Repair Enzymes

Award Year / Program / Phase: 2003 / SBIR / Phase II
Agency: HHS
Principal Investigator: Leonard S. Bazar
Award Amount: $842,155.00
Abstract:
DESCRIPTION (provided by applicant): Trevigen/TreviMed has developed the Mutation Identification DNA Analysis System (MIDAS TM) that relies on DNA mismatch repair enzymes (MREs) for the detection and identification of known point mutations and pathogen DNA without the need for PCR amplification. The… More

Lateral Flow Assay for Oncogenic Strains of HPV

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Leonard S. Bazar
Award Amount: $107,000.00
Abstract:
DESCRIPTION (provided by applicant): Trevigen/TreviMed has developed the Mismatch Identification DNA Analysis System (MIDAS) that relies on SNIPase (genetically-optimized DNA mismatch repair enzymes) for the detection of pathogen DNA without the need for PCR amplification. The purpose of the… More

New Sensitive Detection of Food and Water Borne Pathogens

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jay George
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): The Centers for Disease Control and Prevention (CDC) estimate that, in the United States, there are in excess of 75 million illnesses per year, 300,000 hospitalizations, and 5,000 deaths annually that are directly attr ibuted to food-borne pathogens [1]. E. coli… More

Development of a standard high throughput comet assay

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency: HHS
Principal Investigator: Janos Luka
Award Amount: $975,944.00
Abstract:
DESCRIPTION (provided by applicant): The single cell gel electrophoresis (SCGE) or comet assay is now recognized worldwide as a simple and inexpensive method for detection of different types of DNA damage. Adoption of the comet assay for genotoxic studies has been hampered to date by the lack of a… More

DNA-Based Lateral Flow Assay for Oncogenic Strains of HPV

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency: HHS
Principal Investigator: Leonard S. Bazar
Award Amount: $698,714.00
Abstract:
DESCRIPTION (provided by applicant): Human Papilloma Virus (HPV) comprises a family of viruses of over 100 different strains. The high-risk strains of HPV cause cervical cancer, which is the second leading cause of female cancer mortality worldwide with 288,000 deaths yearly. The goal of the… More

Development of LAMP-Comet and Immuno-Comet Assays

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $291,838.00
Abstract:
DESCRIPTION (provided by applicant): The single cell gel electrophoresis (SCGE) or Comet assay, is now internationally recognized as a simple and inexpensive method for the detection of different types of DNA damage, including single- and double- strande d breaks, DNA adducts, cross-links, and… More

DNA repair deficient human cells for genomic variation analysis

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jay George
Award Amount: $200,257.00
Abstract:
DESCRIPTION (provided by applicant): Human illness results from the complex interactions of integrated processes and factors, including genetic predispositions and environmental agents. The environmental genome project (EGP) was formally initiated to syste matically and comprehensively evaluate how… More

DNA repair deficient cells for analysis

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: HHS
Principal Investigator: Jay George
Award Amount: $2,526,826.00
Abstract:
DESCRIPTION (provided by applicant): Successful completion of Phase I led to the development a panel of human cell lines, each deficient in one of the eleven DNA glycosylase enzymes. Depletion of target mRNA was as high as 95%, with corresponding depletion of target protein levels and enzymatic… More

DNA Repair-on-a-Chip: Spatially Encoded Microwell Arrays

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jay George – 301-216-2800
Award Amount: $318,784.00
Abstract:
DESCRIPTION (provided by applicant): Human exposure to dangerous genotoxins is unavoidable, as DNA damaging agents are ubiquitous both in our environment and within our cells. DNA damaging agents and other genotoxins that arise from cellular metabolism, environmental sources or disease-related… More

Discovery Tools for Chemotherapy Resistance to Cell Death.

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jay George – 301-216-2800
Award Amount: $216,878.00
Abstract:
DESCRIPTION (provided by applicant): Apoptosis is an evolutionarily conserved cell death process that involves over 100 gene products. In response to cellular stress or to maintain tissue homeostasis, the apoptotic machinery initiates and carries out a series of biochemical events leading to cell… More

DNA Repair-on-a-Chip: Spatially Encoded Microwell Arrays

Award Year / Program / Phase: 2013 / SBIR / Phase II
Agency: HHS
Principal Investigator: Jay George – 301-216-2800
Award Amount: $1,500,000.00
Abstract:
Project Summary / Abstract Preserving genomic integrity is essential in order to suppress cancer, neurodegeneration, aging and other diseases. At odds with genomic preservation is DNA damage, which can drive mutations, sequence rearrangements and cellulartoxicity. DNA damage is unavoidable, as DNA… More