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Oligonucleotides Inhibition of HIV-1 Integrase

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
24785
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
24785
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Triplex Pharmaceutical
9391 Grogans Mill Road The Woodlands, TX 77380
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Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1994
Title: Oligonucleotides Inhibition of HIV-1 Integrase
Agency: HHS
Contract: 1 R43 AI36115-1,
Award Amount: $65,956.00
 

Abstract:

Effective therapy for human immunodeficiency virus (HIV) infection remains elusive, partly dueto the fact that infected long lived cells provide a reservoir for the virus. Currently availableanti-retroviral agents are reverse transcriptase inhibitors. In spite of their success, these compoundshave limited utility because their toxicity and lack of action have no effect on the production ofinfectious virus in cells harboring integrated provirus. Therefore, it is important to alternative approacheswhich target other factors important to the life cycle of the virus. This approach would involve targetingcompounds which interfere with the viral integrate enzyme in the HIV life cycle. Development ofclinically tolerable inhibitors of HIV integrate would have profound implications for anti- retroviral therapyby offering a wide range of application including potential synergy with the currently available reversetranscriptase inhibitors in acute HIV infections and as agents to target HIV-1 in chronically infected cells.We will design inhibitors targeted to HIV integrate and evaluate their therapeutic utility using in vitroassay systems. The promising compounds will further be evaluated in tissue culture and in vivo assaysystems.

Principal Investigator:

Joshua Ojwang
7133638761

Business Contact:

Small Business Information at Submission:

Triplex Pharmaceutical
9391 Grogans Mill Road The Woodlands, TX 77380

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No