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Active Anti-HIV Guanosine/Thymidine Oligonucleotides

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29101
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
29101
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Triplex Pharmaceutical
9391 Grogans Mill Road The Woodlands, TX 77380
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Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1995
Title: Active Anti-HIV Guanosine/Thymidine Oligonucleotides
Agency: HHS
Contract: 1 R43 AI37332-01A1,
Award Amount: $100,000.00
 

Abstract:

We will develop a new class of oligonucleotides, which fold themselves into ordered structures andmainly of deoxyguanosine and deoxythymidine (GTOs), as therapeutic antiviral agents active against HGTOs as antiviral agents represents the results of a productive investigation into the mechanism bymediate antiviral activity. Experiments described in the following preliminary results section demonguanosine/thymidine compound I100-15, with a phosphodiester (PD) backbone, is able to suppress HIV-1after removal of the drug from the viral infected cell culture is folded into an intramolecular strutranscription; may inhibit critical portions of HIV-1 replication and is not working by blocking virinteraction with the viral v3 loop. The experiments proposed in this Phase I grant application are svalidate the anti-human immunodeficiency virus type 1 (HIV-1) efficacy of 1100-15 by determining thestructure of this molecule and establishing the anti-HIV-1 mechanism of action. A secondary goal ofobtained structural information to rationally design modifications which will increase the anti-HIV-

Principal Investigator:

Robert Rando
71363

Business Contact:

Small Business Information at Submission:

Triplex Pharmaceutical
9391 Grogans Mill Road The Woodlands, TX 77380

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No