Alkenylguanine Analogs--A New Class of Antiviral Agent
1 R43 AI36788-01A1,
We will develop certain structure activity relationships with respect to a novel class of antiviralconduct preliminary experiments designed to define the mechanism of action for these drugs. Preliminestablished that certain alkenes, when attached to a guanine congener, provide potential antiviral atherapeutic indices against debilitating, human, DNA viral infections . We will synthesize additionaactive compounds wherein certain structural variations will be made in the unsaturated hydrocarbon mcomparison of the antiviral activity of these additional derivatives will be used to construct a hypstructural features suggesting the most promising drug candidate. Information from simultaneous studof antiviral action of these drugs will be incorporated into the development of the model.
Small Business Information at Submission:
Principal Investigator:Arthur Lewis
9391 Grogans Mill Road The Woodlands, TX 77380
Number of Employees: