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New Delivery Systems for Therapeutic Oligonucleotides

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29189
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
29189
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Triplex Pharmaceutical
9391 Grogans Mill Road The Woodlands, TX 77380
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Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1995
Title: New Delivery Systems for Therapeutic Oligonucleotides
Agency: HHS
Contract: 1 R43 CA63879-01A1,
Award Amount: $100,000.00
 

Abstract:

Antisense and triple helix-forming oligonucleotides (TFOs) have great potential as therapeutic agenspecifically block the expression of deleterious genes. We will develop novel delivery vehicles, tointernalization and membrane permeability of oligonucleotides. These compounds are polyaminolipids tcationic and lipophilic moieties, and they are designed to be biodegradable and relatively nontoxicutility of the potential uptake enhancers will be validated in a quantitative, anti-oncogene assay shave established sensitive in vitro assays to measure the inhibition of Epidermal Growth Factor Receexpression in glioblastoma cells. The candidate uptake enhancers will be coadministered with anti-EGany gain in the biological efficacy of the TFOs will be quantified. A variety of TFO and polyaminolitested. The toxicity and pharmacokinetic properties of the most effective formulation will be monitoThe most promising uptake enhancers will be tested for in vivo pharmacological activity in Phase IIprinciple, the approach should be of utility in optimizing the cellular delivery of not only oligonupieces of DNA for gene therapy.

Principal Investigator:

Nilabh Chaudhary
71363

Business Contact:

Small Business Information at Submission:

Triplex Pharmaceutical
9391 Grogans Mill Road The Woodlands, TX 77380

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No