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NONDESTRUCTIVE EVALUATION OF DRUGS AND BIOMATERIALS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7298
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7298
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Tronac Inc
1804 South Columbia Lane Orem, UT 84058
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: NONDESTRUCTIVE EVALUATION OF DRUGS AND BIOMATERIALS
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE OBJECTIVE OF THIS RESEARCH IS TO DEVELOP A NONDESTRUCTIVE TECHNIQUE BASED ON MICROWATT BATCH CALORIMETRY TO STUDY THE DEGRADATION OF DRUGS (SOLID-STATE AND LIQUID FORMULATIONS), BIOCHEMICALS, AND BIOMATERIALS (E.G., THOSE USED IN ARTIFICIAL ORGANS). AS A RESEARCH TOOL, THE MICROWATT CALORIMETER IS COMPLEMENTARY TO, AND PROVIDES INFORMATION UNATTAINABLE BY, MORE SPECIFIC METHODS SUCH AS CHROMATOGRAPHY AND SPECTROPHOTOMETRY. THE AIM OF PHASE I IS TO ESTABLISH THE FEASIBILITY OF USING A MICROWATT CALORIMETER TO STUDY THE DEGRADATION OF SOLID-STATE DOSAGE FORMS OF DRUGS AND DRUG MIXTURES. THE EFFECT OF ALTERNATIVE HEAT SINK MATERIALS AND SAMPLE CHAMBERCONFIGURATIONS ON INSTRUMENT EQUILIBRATION, SENSITIVITY, AND ACCURACY WILL ALSO BE INVESTIGATED. IN PHASE II, AN INSTRUMENT WILL BE DESIGNED BASED ON PHASE I RESULTS. THE NEW INSTRUMENT WILL HAVE SOPHISTICATED ELECTRONIC CONTROL AND WILL BE USED TO STUDY A WIDE RANGE OF DRUGS, BIOCHEMICALS, AND BIOMATERIALS. THE SUCCESSFUL COMPLETION OF THIS INVESTIGATION WILL PROVIDE RESEARCHERS WITH A RAPID, ACCURATE, AND RELIABLE INSTRUMENT TO MEASURE OVERALL DECOMPOSITION RATES WITHOUT APPLYING A PHYSICAL OR CHEMICAL STRESS (E.G., DISSOLUTION, HEATING, CHANGES IN IONIC STRENGTH, ETC.). THUS, NEW INSIGHTS INTO THE DEGRADATION PROCESS WILL BE ACHIEVED.

Principal Investigator:

Philip r. brown phd
8012241131

Business Contact:

Small Business Information at Submission:

Tronac Inc
1804 South Columbia Lane Orem, UT 84058

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No